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Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy

Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We found activation of the ATM‐Chk2‐p53 pathway t...

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Detalles Bibliográficos
Autores principales:	Benkafadar, Nesrine, Menardo, Julien, Bourien, Jérôme, Nouvian, Régis, François, Florence, Decaudin, Didier, Maiorano, Domenico, Puel, Jean‐Luc, Wang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210089/ https://www.ncbi.nlm.nih.gov/pubmed/27794029 http://dx.doi.org/10.15252/emmm.201606230

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