Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases

Lysosomal storage disorders (LSDs) are inherited diseases characterized by lysosomal dysfunction and often showing a neurodegenerative course. There is no cure to treat the central nervous system in LSDs. Moreover, the mechanisms driving neuronal degeneration in these pathological conditions remain...

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Detalles Bibliográficos
Autores principales: Sambri, Irene, D'Alessio, Rosa, Ezhova, Yulia, Giuliano, Teresa, Sorrentino, Nicolina Cristina, Cacace, Vincenzo, De Risi, Maria, Cataldi, Mauro, Annunziato, Lucio, De Leonibus, Elvira, Fraldi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210158/
https://www.ncbi.nlm.nih.gov/pubmed/27881461
http://dx.doi.org/10.15252/emmm.201606965

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