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Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

BACKGROUND: Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn seeds followed by seeding of endogenous αSyn. Though it is well known that αSyn...

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Detalles Bibliográficos
Autores principales:	Koller, Emily J., Brooks, Mieu M. T., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210310/ https://www.ncbi.nlm.nih.gov/pubmed/28049533 http://dx.doi.org/10.1186/s13024-016-0142-z

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