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Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions

Conventional methods may fail to identify the cause of pleural effusion (PE), thus establishing reliable biomarkers is deemed necessary. This study aimed at examining the role of vascular endothelial growth factor (VEGF) as a biomarker in the differentiation between malignant and benign PEs in adult...

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Autores principales: Fafliora, Eleftheria, Hatzoglou, Chrissi, Gourgoulianis, Konstantinos I., Zarogiannis, Sotirios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210377/
https://www.ncbi.nlm.nih.gov/pubmed/28039396
http://dx.doi.org/10.14814/phy2.12978
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author Fafliora, Eleftheria
Hatzoglou, Chrissi
Gourgoulianis, Konstantinos I.
Zarogiannis, Sotirios G.
author_facet Fafliora, Eleftheria
Hatzoglou, Chrissi
Gourgoulianis, Konstantinos I.
Zarogiannis, Sotirios G.
author_sort Fafliora, Eleftheria
collection PubMed
description Conventional methods may fail to identify the cause of pleural effusion (PE), thus establishing reliable biomarkers is deemed necessary. This study aimed at examining the role of vascular endothelial growth factor (VEGF) as a biomarker in the differentiation between malignant and benign PEs in adults. A comprehensive literature search in PubMed (Medline), Scopus (ELSEVIER), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted using keywords. We included studies that evaluated pleural and/or serum levels of VEGF among patients presenting with undiagnosed PE and the association between these levels and the final diagnosis. We performed a meta‐analysis to calculate the summary effect using the random effects model. Statistical analysis was performed with the statistical package for meta‐analysis Comprehensive Meta‐Analysis. Twenty studies were included in the systematic review, while 11 of them in the meta‐analysis. Pleural fluid VEGF levels among patients with malignant PE were increased by 1.93 ng/mL as compared to patients with benign PE (95% CI: 1.32–2.54, Q = 173, df (Q): 10, I (2) = 94.2%, P < 0.05). Serum VEGF levels among patients with malignant PE were increased respectively by 1.90 ng/mL (95% CI: 0.93–2.88, Q = 182, df (Q): 6, I (2) = 96.7%, P < 0.05). This study showed that malignant PEs were associated with higher levels of both pleural fluid and serum VEGF. VEGF appears to represent a promising biomarker for the differential diagnosis between benign and malignant PEs.
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spelling pubmed-52103772017-01-05 Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions Fafliora, Eleftheria Hatzoglou, Chrissi Gourgoulianis, Konstantinos I. Zarogiannis, Sotirios G. Physiol Rep Original Research Conventional methods may fail to identify the cause of pleural effusion (PE), thus establishing reliable biomarkers is deemed necessary. This study aimed at examining the role of vascular endothelial growth factor (VEGF) as a biomarker in the differentiation between malignant and benign PEs in adults. A comprehensive literature search in PubMed (Medline), Scopus (ELSEVIER), and Cochrane Central Register of Controlled Trials (CENTRAL) databases was conducted using keywords. We included studies that evaluated pleural and/or serum levels of VEGF among patients presenting with undiagnosed PE and the association between these levels and the final diagnosis. We performed a meta‐analysis to calculate the summary effect using the random effects model. Statistical analysis was performed with the statistical package for meta‐analysis Comprehensive Meta‐Analysis. Twenty studies were included in the systematic review, while 11 of them in the meta‐analysis. Pleural fluid VEGF levels among patients with malignant PE were increased by 1.93 ng/mL as compared to patients with benign PE (95% CI: 1.32–2.54, Q = 173, df (Q): 10, I (2) = 94.2%, P < 0.05). Serum VEGF levels among patients with malignant PE were increased respectively by 1.90 ng/mL (95% CI: 0.93–2.88, Q = 182, df (Q): 6, I (2) = 96.7%, P < 0.05). This study showed that malignant PEs were associated with higher levels of both pleural fluid and serum VEGF. VEGF appears to represent a promising biomarker for the differential diagnosis between benign and malignant PEs. John Wiley and Sons Inc. 2016-12-27 /pmc/articles/PMC5210377/ /pubmed/28039396 http://dx.doi.org/10.14814/phy2.12978 Text en © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Fafliora, Eleftheria
Hatzoglou, Chrissi
Gourgoulianis, Konstantinos I.
Zarogiannis, Sotirios G.
Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title_full Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title_fullStr Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title_full_unstemmed Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title_short Systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
title_sort systematic review and meta‐analysis of vascular endothelial growth factor as a biomarker for malignant pleural effusions
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210377/
https://www.ncbi.nlm.nih.gov/pubmed/28039396
http://dx.doi.org/10.14814/phy2.12978
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