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Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis

BACKGROUND: Considerable controversy exists on the association between retinal vein occlusion (RVO) and stroke risk. Therefore, we conducted a meta‐analysis to assess the relationship between RVO and stroke risk. METHODS AND RESULTS: PubMed, EMBASE, and the Cochrane library databases were searched f...

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Autores principales: Li, Min, Hu, Xiaolan, Huang, Jiangtao, Tan, Yuan, Yang, Baoping, Tang, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210429/
https://www.ncbi.nlm.nih.gov/pubmed/28007745
http://dx.doi.org/10.1161/JAHA.116.004703
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author Li, Min
Hu, Xiaolan
Huang, Jiangtao
Tan, Yuan
Yang, Baoping
Tang, Zhenyu
author_facet Li, Min
Hu, Xiaolan
Huang, Jiangtao
Tan, Yuan
Yang, Baoping
Tang, Zhenyu
author_sort Li, Min
collection PubMed
description BACKGROUND: Considerable controversy exists on the association between retinal vein occlusion (RVO) and stroke risk. Therefore, we conducted a meta‐analysis to assess the relationship between RVO and stroke risk. METHODS AND RESULTS: PubMed, EMBASE, and the Cochrane library databases were searched for cohort studies with data on RVO and stroke risk. Studies that reported adjusted relative risks (RRs) with 95% CIs of stroke associated with RVO were included. Stratified analyses were conducted according to key characteristics. A total of 5 articles including results from 6 prospective cohort studies with 431 cases of stroke and 37 471 participants were included in the meta‐analysis. Overall, after adjustment for established cardiovascular risk factors, participants with RVO at baseline were considerably more associated with a greater incidence of stroke risk (combined RR: 1.50, 95% CI: 1.19–1.90), compared to participants without RVO. The results were more pronounced for stroke (RR: 1.72, 95% CI: 1.24–2.37) in the stratified with a stroke history. The risk of stroke was nonsignificant in male subjects (RR: 1.20, 95% CI: 0.96–1.49) and in female subjects (RR: 0.93, 95% CI: 0.64–1.34). The presence of both central RVO (RR: 1.90, 95% CI: 1.46–2.48) and branch RVO (RR: 1.79, 95% CI: 1.18–2.72) was associated with increased risk of stroke. Stratifying by age, the associations between RVO and risk of stroke were similar between the age range in the cohorts that ranged from 50 to 59 years and 60 to 69 years. CONCLUSIONS: Exposure to RVO was associated with an increased risk of stroke, especially in subjects aged between 50 and 69 years. Future studies on the effect of RVO treatment and modifiable risk factor reduction on stroke risk in RVO patients are warranted.
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spelling pubmed-52104292017-01-05 Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis Li, Min Hu, Xiaolan Huang, Jiangtao Tan, Yuan Yang, Baoping Tang, Zhenyu J Am Heart Assoc Systematic Review and Meta‐Analysis BACKGROUND: Considerable controversy exists on the association between retinal vein occlusion (RVO) and stroke risk. Therefore, we conducted a meta‐analysis to assess the relationship between RVO and stroke risk. METHODS AND RESULTS: PubMed, EMBASE, and the Cochrane library databases were searched for cohort studies with data on RVO and stroke risk. Studies that reported adjusted relative risks (RRs) with 95% CIs of stroke associated with RVO were included. Stratified analyses were conducted according to key characteristics. A total of 5 articles including results from 6 prospective cohort studies with 431 cases of stroke and 37 471 participants were included in the meta‐analysis. Overall, after adjustment for established cardiovascular risk factors, participants with RVO at baseline were considerably more associated with a greater incidence of stroke risk (combined RR: 1.50, 95% CI: 1.19–1.90), compared to participants without RVO. The results were more pronounced for stroke (RR: 1.72, 95% CI: 1.24–2.37) in the stratified with a stroke history. The risk of stroke was nonsignificant in male subjects (RR: 1.20, 95% CI: 0.96–1.49) and in female subjects (RR: 0.93, 95% CI: 0.64–1.34). The presence of both central RVO (RR: 1.90, 95% CI: 1.46–2.48) and branch RVO (RR: 1.79, 95% CI: 1.18–2.72) was associated with increased risk of stroke. Stratifying by age, the associations between RVO and risk of stroke were similar between the age range in the cohorts that ranged from 50 to 59 years and 60 to 69 years. CONCLUSIONS: Exposure to RVO was associated with an increased risk of stroke, especially in subjects aged between 50 and 69 years. Future studies on the effect of RVO treatment and modifiable risk factor reduction on stroke risk in RVO patients are warranted. John Wiley and Sons Inc. 2016-12-22 /pmc/articles/PMC5210429/ /pubmed/28007745 http://dx.doi.org/10.1161/JAHA.116.004703 Text en © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Systematic Review and Meta‐Analysis
Li, Min
Hu, Xiaolan
Huang, Jiangtao
Tan, Yuan
Yang, Baoping
Tang, Zhenyu
Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title_full Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title_fullStr Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title_full_unstemmed Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title_short Impact of Retinal Vein Occlusion on Stroke Incidence: A Meta‐Analysis
title_sort impact of retinal vein occlusion on stroke incidence: a meta‐analysis
topic Systematic Review and Meta‐Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210429/
https://www.ncbi.nlm.nih.gov/pubmed/28007745
http://dx.doi.org/10.1161/JAHA.116.004703
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