Cargando…

Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüppel‐Like Factor 4 (AMPK/KLF4) Signaling

BACKGROUND: Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sunaga, Hiroaki, Matsui, Hiroki, Anjo, Saki, Syamsunarno, Mas Risky A. A., Koitabashi, Norimichi, Iso, Tatsuya, Matsuzaka, Takashi, Shimano, Hitoshi, Yokoyama, Tomoyuki, Kurabayashi, Masahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210431/ https://www.ncbi.nlm.nih.gov/pubmed/27881420 http://dx.doi.org/10.1161/JAHA.116.004014

Ejemplares similares

Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress
por: Syamsunarno, Mas Rizky A. A., et al.
Publicado: (2014)

Pathophysiological role of fatty acid‐binding protein 4 in Asian patients with heart failure and preserved ejection fraction
por: Harada, Tomonari, et al.
Publicado: (2020)

The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
por: Kiyoki, Yusuke, et al.
Publicado: (2023)

Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy
por: Umbarawan, Yogi, et al.
Publicado: (2020)

Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice
por: Umbarawan, Yogi, et al.
Publicado: (2021)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice
por: Umbarawan, Yogi, et al.
Publicado: (2018)

P428: THE FATTY ACID ELONGASE ELOVL6 IS CRUCIAL FOR HEMATOPOIETIC STEM CELL ENGRAFTMENT AND LEUKEMIA PROPAGATION
por: Kiyoki, Yusuke, et al.
Publicado: (2023)

Prognostic impact of elevated fatty acid‐binding protein 1 in patients with heart failure
por: Kagami, Kazuki, et al.
Publicado: (2021)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure
por: Umbarawan, Yogi, et al.
Publicado: (2018)

A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting
por: Syamsunarno, Mas Rizky A. A., et al.
Publicado: (2013)

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men
por: Korbecki, Jan, et al.
Publicado: (2022)

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
por: Tikhonenko, Maria, et al.
Publicado: (2010)

ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma
por: Nitta, Satoshi, et al.
Publicado: (2022)

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation
por: Nakamura, Yoshiyuki, et al.
Publicado: (2018)

Two Modes of Regulation of the Fatty Acid Elongase ELOVL6 by the 3-Ketoacyl-CoA Reductase KAR in the Fatty Acid Elongation Cycle
por: Naganuma, Tatsuro, et al.
Publicado: (2014)

Polymorphism in the ELOVL6 Gene Is Associated with a Major QTL Effect on Fatty Acid Composition in Pigs
por: Corominas, Jordi, et al.
Publicado: (2013)

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
por: Logan, Sreemathi, et al.
Publicado: (2014)

Cloning and expression characterization of elongation of very long-chain fatty acids protein 6 (elovl6) with dietary fatty acids, ambient salinity and starvation stress in Scylla paramamosain
por: Lin, Zhideng, et al.
Publicado: (2023)

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice
por: Kikuchi, Manami, et al.
Publicado: (2016)

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance
por: Moon, Young-Ah, et al.
Publicado: (2014)

Epigenetic regulation of the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs
por: Corominas, Jordi, et al.
Publicado: (2015)

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
por: Hopiavuori, Blake R., et al.
Publicado: (2018)

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
por: Deák, Ferenc, et al.
Publicado: (2019)

DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
por: Furukawa, Nozomi, et al.
Publicado: (2020)

Cardiac Metabolism and Contractile Function in Mice with Reduced Trans-Endothelial Fatty Acid Transport
por: Iso, Tatsuya, et al.
Publicado: (2021)

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
por: Yeboah, Gyening Kofi, et al.
Publicado: (2021)

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
por: Gyening, Yeboah Kofi, et al.
Publicado: (2022)

rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
por: Pan, Gang, et al.
Publicado: (2020)

Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis
por: Tung, Brian, et al.
Publicado: (2018)

Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
por: Sunaga, Hiroaki, et al.
Publicado: (2019)

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
por: Cameron, D. Joshua, et al.
Publicado: (2007)

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
por: Ofman, Rob, et al.
Publicado: (2010)

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase
por: Robichaud, Philippe-Pierre, et al.
Publicado: (2018)

Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis
por: Sun, Shouxiang, et al.
Publicado: (2021)

Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat
por: Weiss-Hersh, Kathrin, et al.
Publicado: (2019)

Association Analysis between Genetic Variants of elovl5a and elovl5b and Poly-Unsaturated Fatty Acids in Common Carp (Cyprinus carpio)
por: Zhang, Yan, et al.
Publicado: (2022)

Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation123
por: Fang, Jiahua, et al.
Publicado: (2016)

Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells
por: Shi, Hengbo, et al.
Publicado: (2019)

Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction
por: Harada, Tomonari, et al.
Publicado: (2021)

Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart
por: Kawakami, Ryo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h2ikp6i64mu6qr3kelcrpb8jcr