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Genenames.org: the HGNC and VGNC resources in 2017

The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming...

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Autores principales: Yates, Bethan, Braschi, Bryony, Gray, Kristian A., Seal, Ruth L., Tweedie, Susan, Bruford, Elspeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210531/
https://www.ncbi.nlm.nih.gov/pubmed/27799471
http://dx.doi.org/10.1093/nar/gkw1033
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author Yates, Bethan
Braschi, Bryony
Gray, Kristian A.
Seal, Ruth L.
Tweedie, Susan
Bruford, Elspeth A.
author_facet Yates, Bethan
Braschi, Bryony
Gray, Kristian A.
Seal, Ruth L.
Tweedie, Susan
Bruford, Elspeth A.
author_sort Yates, Bethan
collection PubMed
description The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org. In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years.
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spelling pubmed-52105312017-01-05 Genenames.org: the HGNC and VGNC resources in 2017 Yates, Bethan Braschi, Bryony Gray, Kristian A. Seal, Ruth L. Tweedie, Susan Bruford, Elspeth A. Nucleic Acids Res Database Issue The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org. In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years. Oxford University Press 2017-01-04 2016-10-30 /pmc/articles/PMC5210531/ /pubmed/27799471 http://dx.doi.org/10.1093/nar/gkw1033 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Yates, Bethan
Braschi, Bryony
Gray, Kristian A.
Seal, Ruth L.
Tweedie, Susan
Bruford, Elspeth A.
Genenames.org: the HGNC and VGNC resources in 2017
title Genenames.org: the HGNC and VGNC resources in 2017
title_full Genenames.org: the HGNC and VGNC resources in 2017
title_fullStr Genenames.org: the HGNC and VGNC resources in 2017
title_full_unstemmed Genenames.org: the HGNC and VGNC resources in 2017
title_short Genenames.org: the HGNC and VGNC resources in 2017
title_sort genenames.org: the hgnc and vgnc resources in 2017
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210531/
https://www.ncbi.nlm.nih.gov/pubmed/27799471
http://dx.doi.org/10.1093/nar/gkw1033
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