Cargando…
Genenames.org: the HGNC and VGNC resources in 2017
The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210531/ https://www.ncbi.nlm.nih.gov/pubmed/27799471 http://dx.doi.org/10.1093/nar/gkw1033 |
_version_ | 1782490901599223808 |
---|---|
author | Yates, Bethan Braschi, Bryony Gray, Kristian A. Seal, Ruth L. Tweedie, Susan Bruford, Elspeth A. |
author_facet | Yates, Bethan Braschi, Bryony Gray, Kristian A. Seal, Ruth L. Tweedie, Susan Bruford, Elspeth A. |
author_sort | Yates, Bethan |
collection | PubMed |
description | The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org. In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years. |
format | Online Article Text |
id | pubmed-5210531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52105312017-01-05 Genenames.org: the HGNC and VGNC resources in 2017 Yates, Bethan Braschi, Bryony Gray, Kristian A. Seal, Ruth L. Tweedie, Susan Bruford, Elspeth A. Nucleic Acids Res Database Issue The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently the HGNC database contains almost 40 000 approved gene symbols, over 19 000 of which represent protein-coding genes. In addition to naming genomic loci we manually curate genes into family sets based on shared characteristics such as homology, function or phenotype. We have recently updated our gene family resources and introduced new improved visualizations which can be seen alongside our gene symbol reports on our primary website http://www.genenames.org. In 2016 we expanded our remit and formed the Vertebrate Gene Nomenclature Committee (VGNC) which is responsible for assigning names to vertebrate species lacking a dedicated nomenclature group. Using the chimpanzee genome as a pilot project we have approved symbols and names for over 14 500 protein-coding genes in chimpanzee, and have developed a new website http://vertebrate.genenames.org to distribute these data. Here, we review our online data and resources, focusing particularly on the improvements and new developments made during the last two years. Oxford University Press 2017-01-04 2016-10-30 /pmc/articles/PMC5210531/ /pubmed/27799471 http://dx.doi.org/10.1093/nar/gkw1033 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Yates, Bethan Braschi, Bryony Gray, Kristian A. Seal, Ruth L. Tweedie, Susan Bruford, Elspeth A. Genenames.org: the HGNC and VGNC resources in 2017 |
title | Genenames.org: the HGNC and VGNC resources in 2017 |
title_full | Genenames.org: the HGNC and VGNC resources in 2017 |
title_fullStr | Genenames.org: the HGNC and VGNC resources in 2017 |
title_full_unstemmed | Genenames.org: the HGNC and VGNC resources in 2017 |
title_short | Genenames.org: the HGNC and VGNC resources in 2017 |
title_sort | genenames.org: the hgnc and vgnc resources in 2017 |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210531/ https://www.ncbi.nlm.nih.gov/pubmed/27799471 http://dx.doi.org/10.1093/nar/gkw1033 |
work_keys_str_mv | AT yatesbethan genenamesorgthehgncandvgncresourcesin2017 AT braschibryony genenamesorgthehgncandvgncresourcesin2017 AT graykristiana genenamesorgthehgncandvgncresourcesin2017 AT sealruthl genenamesorgthehgncandvgncresourcesin2017 AT tweediesusan genenamesorgthehgncandvgncresourcesin2017 AT brufordelspetha genenamesorgthehgncandvgncresourcesin2017 |