Open Targets: a platform for therapeutic target identification and validation

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is...

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Detalles Bibliográficos
Autores principales: Koscielny, Gautier, An, Peter, Carvalho-Silva, Denise, Cham, Jennifer A., Fumis, Luca, Gasparyan, Rippa, Hasan, Samiul, Karamanis, Nikiforos, Maguire, Michael, Papa, Eliseo, Pierleoni, Andrea, Pignatelli, Miguel, Platt, Theo, Rowland, Francis, Wankar, Priyanka, Bento, A. Patrícia, Burdett, Tony, Fabregat, Antonio, Forbes, Simon, Gaulton, Anna, Gonzalez, Cristina Yenyxe, Hermjakob, Henning, Hersey, Anne, Jupe, Steven, Kafkas, Şenay, Keays, Maria, Leroy, Catherine, Lopez, Francisco-Javier, Magarinos, Maria Paula, Malone, James, McEntyre, Johanna, Munoz-Pomer Fuentes, Alfonso, O'Donovan, Claire, Papatheodorou, Irene, Parkinson, Helen, Palka, Barbara, Paschall, Justin, Petryszak, Robert, Pratanwanich, Naruemon, Sarntivijal, Sirarat, Saunders, Gary, Sidiropoulos, Konstantinos, Smith, Thomas, Sondka, Zbyslaw, Stegle, Oliver, Tang, Y. Amy, Turner, Edward, Vaughan, Brendan, Vrousgou, Olga, Watkins, Xavier, Martin, Maria-Jesus, Sanseau, Philippe, Vamathevan, Jessica, Birney, Ewan, Barrett, Jeffrey, Dunham, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210543/
https://www.ncbi.nlm.nih.gov/pubmed/27899665
http://dx.doi.org/10.1093/nar/gkw1055
Descripción
Sumario:We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.

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