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Open Targets: a platform for therapeutic target identification and validation
We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210543/ https://www.ncbi.nlm.nih.gov/pubmed/27899665 http://dx.doi.org/10.1093/nar/gkw1055 |
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| author | Koscielny, Gautier An, Peter Carvalho-Silva, Denise Cham, Jennifer A. Fumis, Luca Gasparyan, Rippa Hasan, Samiul Karamanis, Nikiforos Maguire, Michael Papa, Eliseo Pierleoni, Andrea Pignatelli, Miguel Platt, Theo Rowland, Francis Wankar, Priyanka Bento, A. Patrícia Burdett, Tony Fabregat, Antonio Forbes, Simon Gaulton, Anna Gonzalez, Cristina Yenyxe Hermjakob, Henning Hersey, Anne Jupe, Steven Kafkas, Şenay Keays, Maria Leroy, Catherine Lopez, Francisco-Javier Magarinos, Maria Paula Malone, James McEntyre, Johanna Munoz-Pomer Fuentes, Alfonso O'Donovan, Claire Papatheodorou, Irene Parkinson, Helen Palka, Barbara Paschall, Justin Petryszak, Robert Pratanwanich, Naruemon Sarntivijal, Sirarat Saunders, Gary Sidiropoulos, Konstantinos Smith, Thomas Sondka, Zbyslaw Stegle, Oliver Tang, Y. Amy Turner, Edward Vaughan, Brendan Vrousgou, Olga Watkins, Xavier Martin, Maria-Jesus Sanseau, Philippe Vamathevan, Jessica Birney, Ewan Barrett, Jeffrey Dunham, Ian |
| author_facet | Koscielny, Gautier An, Peter Carvalho-Silva, Denise Cham, Jennifer A. Fumis, Luca Gasparyan, Rippa Hasan, Samiul Karamanis, Nikiforos Maguire, Michael Papa, Eliseo Pierleoni, Andrea Pignatelli, Miguel Platt, Theo Rowland, Francis Wankar, Priyanka Bento, A. Patrícia Burdett, Tony Fabregat, Antonio Forbes, Simon Gaulton, Anna Gonzalez, Cristina Yenyxe Hermjakob, Henning Hersey, Anne Jupe, Steven Kafkas, Şenay Keays, Maria Leroy, Catherine Lopez, Francisco-Javier Magarinos, Maria Paula Malone, James McEntyre, Johanna Munoz-Pomer Fuentes, Alfonso O'Donovan, Claire Papatheodorou, Irene Parkinson, Helen Palka, Barbara Paschall, Justin Petryszak, Robert Pratanwanich, Naruemon Sarntivijal, Sirarat Saunders, Gary Sidiropoulos, Konstantinos Smith, Thomas Sondka, Zbyslaw Stegle, Oliver Tang, Y. Amy Turner, Edward Vaughan, Brendan Vrousgou, Olga Watkins, Xavier Martin, Maria-Jesus Sanseau, Philippe Vamathevan, Jessica Birney, Ewan Barrett, Jeffrey Dunham, Ian |
| author_sort | Koscielny, Gautier |
| collection | PubMed |
| description | We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org. |
| format | Online Article Text |
| id | pubmed-5210543 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-52105432017-01-05 Open Targets: a platform for therapeutic target identification and validation Koscielny, Gautier An, Peter Carvalho-Silva, Denise Cham, Jennifer A. Fumis, Luca Gasparyan, Rippa Hasan, Samiul Karamanis, Nikiforos Maguire, Michael Papa, Eliseo Pierleoni, Andrea Pignatelli, Miguel Platt, Theo Rowland, Francis Wankar, Priyanka Bento, A. Patrícia Burdett, Tony Fabregat, Antonio Forbes, Simon Gaulton, Anna Gonzalez, Cristina Yenyxe Hermjakob, Henning Hersey, Anne Jupe, Steven Kafkas, Şenay Keays, Maria Leroy, Catherine Lopez, Francisco-Javier Magarinos, Maria Paula Malone, James McEntyre, Johanna Munoz-Pomer Fuentes, Alfonso O'Donovan, Claire Papatheodorou, Irene Parkinson, Helen Palka, Barbara Paschall, Justin Petryszak, Robert Pratanwanich, Naruemon Sarntivijal, Sirarat Saunders, Gary Sidiropoulos, Konstantinos Smith, Thomas Sondka, Zbyslaw Stegle, Oliver Tang, Y. Amy Turner, Edward Vaughan, Brendan Vrousgou, Olga Watkins, Xavier Martin, Maria-Jesus Sanseau, Philippe Vamathevan, Jessica Birney, Ewan Barrett, Jeffrey Dunham, Ian Nucleic Acids Res Database Issue We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org. Oxford University Press 2017-01-04 2016-12-08 /pmc/articles/PMC5210543/ /pubmed/27899665 http://dx.doi.org/10.1093/nar/gkw1055 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Database Issue Koscielny, Gautier An, Peter Carvalho-Silva, Denise Cham, Jennifer A. Fumis, Luca Gasparyan, Rippa Hasan, Samiul Karamanis, Nikiforos Maguire, Michael Papa, Eliseo Pierleoni, Andrea Pignatelli, Miguel Platt, Theo Rowland, Francis Wankar, Priyanka Bento, A. Patrícia Burdett, Tony Fabregat, Antonio Forbes, Simon Gaulton, Anna Gonzalez, Cristina Yenyxe Hermjakob, Henning Hersey, Anne Jupe, Steven Kafkas, Şenay Keays, Maria Leroy, Catherine Lopez, Francisco-Javier Magarinos, Maria Paula Malone, James McEntyre, Johanna Munoz-Pomer Fuentes, Alfonso O'Donovan, Claire Papatheodorou, Irene Parkinson, Helen Palka, Barbara Paschall, Justin Petryszak, Robert Pratanwanich, Naruemon Sarntivijal, Sirarat Saunders, Gary Sidiropoulos, Konstantinos Smith, Thomas Sondka, Zbyslaw Stegle, Oliver Tang, Y. Amy Turner, Edward Vaughan, Brendan Vrousgou, Olga Watkins, Xavier Martin, Maria-Jesus Sanseau, Philippe Vamathevan, Jessica Birney, Ewan Barrett, Jeffrey Dunham, Ian Open Targets: a platform for therapeutic target identification and validation |
| title | Open Targets: a platform for therapeutic target identification and validation |
| title_full | Open Targets: a platform for therapeutic target identification and validation |
| title_fullStr | Open Targets: a platform for therapeutic target identification and validation |
| title_full_unstemmed | Open Targets: a platform for therapeutic target identification and validation |
| title_short | Open Targets: a platform for therapeutic target identification and validation |
| title_sort | open targets: a platform for therapeutic target identification and validation |
| topic | Database Issue |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210543/ https://www.ncbi.nlm.nih.gov/pubmed/27899665 http://dx.doi.org/10.1093/nar/gkw1055 |
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