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POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins

We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR su...

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Detalles Bibliográficos
Autores principales: Hu, Boqin, Yang, Yu-Cheng T., Huang, Yiming, Zhu, Yumin, Lu, Zhi John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210617/
https://www.ncbi.nlm.nih.gov/pubmed/28053162
http://dx.doi.org/10.1093/nar/gkw888
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author Hu, Boqin
Yang, Yu-Cheng T.
Huang, Yiming
Zhu, Yumin
Lu, Zhi John
author_facet Hu, Boqin
Yang, Yu-Cheng T.
Huang, Yiming
Zhu, Yumin
Lu, Zhi John
author_sort Hu, Boqin
collection PubMed
description We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (∼23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases.
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spelling pubmed-52106172017-01-05 POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins Hu, Boqin Yang, Yu-Cheng T. Huang, Yiming Zhu, Yumin Lu, Zhi John Nucleic Acids Res Database Issue We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (∼23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases. Oxford University Press 2017-01-04 2016-10-05 /pmc/articles/PMC5210617/ /pubmed/28053162 http://dx.doi.org/10.1093/nar/gkw888 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Database Issue
Hu, Boqin
Yang, Yu-Cheng T.
Huang, Yiming
Zhu, Yumin
Lu, Zhi John
POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title_full POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title_fullStr POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title_full_unstemmed POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title_short POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
title_sort postar: a platform for exploring post-transcriptional regulation coordinated by rna-binding proteins
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210617/
https://www.ncbi.nlm.nih.gov/pubmed/28053162
http://dx.doi.org/10.1093/nar/gkw888
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