Cargando…
POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR su...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210617/ https://www.ncbi.nlm.nih.gov/pubmed/28053162 http://dx.doi.org/10.1093/nar/gkw888 |
_version_ | 1782490920519729152 |
---|---|
author | Hu, Boqin Yang, Yu-Cheng T. Huang, Yiming Zhu, Yumin Lu, Zhi John |
author_facet | Hu, Boqin Yang, Yu-Cheng T. Huang, Yiming Zhu, Yumin Lu, Zhi John |
author_sort | Hu, Boqin |
collection | PubMed |
description | We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (∼23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases. |
format | Online Article Text |
id | pubmed-5210617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52106172017-01-05 POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins Hu, Boqin Yang, Yu-Cheng T. Huang, Yiming Zhu, Yumin Lu, Zhi John Nucleic Acids Res Database Issue We present POSTAR (http://POSTAR.ncrnalab.org), a resource of POST-trAnscriptional Regulation coordinated by RNA-binding proteins (RBPs). Precise characterization of post-transcriptional regulatory maps has accelerated dramatically in the past few years. Based on new studies and resources, POSTAR supplies the largest collection of experimentally probed (∼23 million) and computationally predicted (approximately 117 million) RBP binding sites in the human and mouse transcriptomes. POSTAR annotates every transcript and its RBP binding sites using extensive information regarding various molecular regulatory events (e.g., splicing, editing, and modification), RNA secondary structures, disease-associated variants, and gene expression and function. Moreover, POSTAR provides a friendly, multi-mode, integrated search interface, which helps users to connect multiple RBP binding sites with post-transcriptional regulatory events, phenotypes, and diseases. Based on our platform, we were able to obtain novel insights into post-transcriptional regulation, such as the putative association between CPSF6 binding, RNA structural domains, and Li-Fraumeni syndrome SNPs. In summary, POSTAR represents an early effort to systematically annotate post-transcriptional regulatory maps and explore the putative roles of RBPs in human diseases. Oxford University Press 2017-01-04 2016-10-05 /pmc/articles/PMC5210617/ /pubmed/28053162 http://dx.doi.org/10.1093/nar/gkw888 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Hu, Boqin Yang, Yu-Cheng T. Huang, Yiming Zhu, Yumin Lu, Zhi John POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title | POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title_full | POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title_fullStr | POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title_full_unstemmed | POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title_short | POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins |
title_sort | postar: a platform for exploring post-transcriptional regulation coordinated by rna-binding proteins |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210617/ https://www.ncbi.nlm.nih.gov/pubmed/28053162 http://dx.doi.org/10.1093/nar/gkw888 |
work_keys_str_mv | AT huboqin postaraplatformforexploringposttranscriptionalregulationcoordinatedbyrnabindingproteins AT yangyuchengt postaraplatformforexploringposttranscriptionalregulationcoordinatedbyrnabindingproteins AT huangyiming postaraplatformforexploringposttranscriptionalregulationcoordinatedbyrnabindingproteins AT zhuyumin postaraplatformforexploringposttranscriptionalregulationcoordinatedbyrnabindingproteins AT luzhijohn postaraplatformforexploringposttranscriptionalregulationcoordinatedbyrnabindingproteins |