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IGFBP‐3 inhibits Wnt signaling in metastatic melanoma cells

In previous works, we have shown that insulin‐like growth factor‐binding protein‐3 (IGFBP‐3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma. In agreement with the clinical data, recombinant IGFBP‐3 was fou...

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Detalles Bibliográficos
Autores principales: Naspi, Antimo, Zingariello, Maria, Sancillo, Laura, Panasiti, Vincenzo, Polinari, Dorina, Martella, Marianna, Rosa Alba, Rana, Londei, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5213668/
https://www.ncbi.nlm.nih.gov/pubmed/27377812
http://dx.doi.org/10.1002/mc.22525