Vitamin B1-deficient mice show impairment of hippocampus-dependent memory formation and loss of hippocampal neurons and dendritic spines: potential microendophenotypes of Wernicke–Korsakoff syndrome

Patients with severe Wernicke–Korsakoff syndrome (WKS) associated with vitamin B1 (thiamine) deficiency (TD) show enduring impairment of memory formation. The mechanisms of memory impairment induced by TD remain unknown. Here, we show that hippocampal degeneration is a potential microendophenotype (...

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Detalles Bibliográficos
Autores principales: Inaba, Hiroyoshi, Kishimoto, Takuya, Oishi, Satoru, Nagata, Kan, Hasegawa, Shunsuke, Watanabe, Tamae, Kida, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Regular Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5213968/
https://www.ncbi.nlm.nih.gov/pubmed/27576603
http://dx.doi.org/10.1080/09168451.2016.1224639

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