Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Mitochondrial dysfunction underlies many prevalent diseases including heart disease arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy, which selectively removes damaged or unwanted mitochondria, regulated mitochondrial quality and quantity in vivo. Hypoxia ind...

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Detalles Bibliográficos
Autores principales: Zhang, Weilin, Ren, He, Xu, Chunling, Zhu, Chongzhuo, Wu, Hao, Liu, Dong, Wang, Jun, Liu, Lei, Li, Wei, Ma, Qi, Du, Lei, Zheng, Ming, Zhang, Chuanmao, Liu, Junling, Chen, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214169/
https://www.ncbi.nlm.nih.gov/pubmed/27995894
http://dx.doi.org/10.7554/eLife.21407

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