Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma

Follicular lymphoma (FL) is typically an indolent disease, but 30-40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To identify the genetic changes that drive this transformation, we sequenced the exomes of 12 cases with paired FL and tFL biopsies, and identified 45...

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Detalles Bibliográficos
Autores principales: Bouska, Alyssa, Zhang, Weiwei, Gong, Qiang, Iqbal, Javeed, Scuto, Anna, Vose, Julie, Ludvigsen, Maja, Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Delabie, Jan, Jaffe, Elaine S., Braziel, Rita M., Connors, Joseph M., Wu, Chung-I, Staudt, Louis M., D'Amore, Francesco, McKeithan, Timothy W., Chan, Wing C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214175/
https://www.ncbi.nlm.nih.gov/pubmed/27389057
http://dx.doi.org/10.1038/leu.2016.175

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