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Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway

Hepcidin, a peptide hormone, is a key regulator in mammalian iron homeostasis. Increased level of hepcidin due to inflammatory conditions stimulates the ferroportin (FPN) transporter internalization, impairing the iron absorption; clinically manifested as anemia of inflammation (AI). Inhibiting hepc...

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Detalles Bibliográficos
Autores principales:	Angmo, Stanzin, Tripathi, Neha, Abbat, Sheenu, Sharma, Shailesh, Singh, Shelley Sardul, Halder, Avishek, Yadav, Kamalendra, Shukla, Geeta, Sandhir, Rajat, Rishi, Vikas, Bharatam, Prasad V., Yadav, Hariom, Singhal, Nitin Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214259/ https://www.ncbi.nlm.nih.gov/pubmed/28054602 http://dx.doi.org/10.1038/srep40097

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