Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma

Ameloblastin (AMBN), the most abundant non-amelogenin enamel matrix protein, plays a role in ameloblast differentiation. Previously, we found that AMBN promoted osteogenic differentiation via the interaction between CD63 and integrin β1, leading to the inactivation of Src; however, how AMBN affects...

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Detalles Bibliográficos
Autores principales: Ando, Toshinori, Kudo, Yasusei, Iizuka, Shinji, Tsunematsu, Takaaki, Umehara, Hanako, Shrestha, Madhu, Matsuo, Toshihiro, Kubo, Tadahiko, Shimose, Shouji, Arihiro, Koji, Ogawa, Ikuko, Ochi, Mitsuo, Takata, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214574/
https://www.ncbi.nlm.nih.gov/pubmed/28054649
http://dx.doi.org/10.1038/srep40187

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