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Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient complian...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214731/ https://www.ncbi.nlm.nih.gov/pubmed/28049283 http://dx.doi.org/10.3904/kjim.2016.200 |
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author | Lee, Han Hee Choi, Myung-Gyu Hasan, Tayyaba |
author_facet | Lee, Han Hee Choi, Myung-Gyu Hasan, Tayyaba |
author_sort | Lee, Han Hee |
collection | PubMed |
description | Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases. |
format | Online Article Text |
id | pubmed-5214731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-52147312017-01-11 Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? Lee, Han Hee Choi, Myung-Gyu Hasan, Tayyaba Korean J Intern Med Review Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases. The Korean Association of Internal Medicine 2017-01 2017-01-01 /pmc/articles/PMC5214731/ /pubmed/28049283 http://dx.doi.org/10.3904/kjim.2016.200 Text en Copyright © 2017 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lee, Han Hee Choi, Myung-Gyu Hasan, Tayyaba Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title | Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title_full | Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title_fullStr | Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title_full_unstemmed | Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title_short | Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
title_sort | application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214731/ https://www.ncbi.nlm.nih.gov/pubmed/28049283 http://dx.doi.org/10.3904/kjim.2016.200 |
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