Cargando…

Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?

Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient complian...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Han Hee, Choi, Myung-Gyu, Hasan, Tayyaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214731/
https://www.ncbi.nlm.nih.gov/pubmed/28049283
http://dx.doi.org/10.3904/kjim.2016.200
_version_ 1782491658329260032
author Lee, Han Hee
Choi, Myung-Gyu
Hasan, Tayyaba
author_facet Lee, Han Hee
Choi, Myung-Gyu
Hasan, Tayyaba
author_sort Lee, Han Hee
collection PubMed
description Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases.
format Online
Article
Text
id pubmed-5214731
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Korean Association of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-52147312017-01-11 Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? Lee, Han Hee Choi, Myung-Gyu Hasan, Tayyaba Korean J Intern Med Review Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases. The Korean Association of Internal Medicine 2017-01 2017-01-01 /pmc/articles/PMC5214731/ /pubmed/28049283 http://dx.doi.org/10.3904/kjim.2016.200 Text en Copyright © 2017 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lee, Han Hee
Choi, Myung-Gyu
Hasan, Tayyaba
Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title_full Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title_fullStr Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title_full_unstemmed Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title_short Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
title_sort application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214731/
https://www.ncbi.nlm.nih.gov/pubmed/28049283
http://dx.doi.org/10.3904/kjim.2016.200
work_keys_str_mv AT leehanhee applicationofphotodynamictherapyingastrointestinaldisordersanoutdatedorreemergingtechnique
AT choimyunggyu applicationofphotodynamictherapyingastrointestinaldisordersanoutdatedorreemergingtechnique
AT hasantayyaba applicationofphotodynamictherapyingastrointestinaldisordersanoutdatedorreemergingtechnique