A 3D engineered tumour for spatial snap-shot analysis of cell metabolism and phenotype in hypoxic gradients

The profound metabolic reprogramming that occurs in cancer cells has been investigated primarily in two-dimensional cell cultures, which fail to recapitulate spatial aspects of cell-to-cell interactions as well as tissue gradients present in three-dimensional (3D) tumours. Here, we describe an engin...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodenhizer, Darren, Gaude, Edoardo, Cojocari, Dan, Mahadevan, Radhakrishnan, Frezza, Christian, Wouters, Bradly G., McGuigan, Alison P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214740/
https://www.ncbi.nlm.nih.gov/pubmed/26595121
http://dx.doi.org/10.1038/nmat4482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214740/
https://www.ncbi.nlm.nih.gov/pubmed/26595121
http://dx.doi.org/10.1038/nmat4482

Ejemplares similares