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A 3D engineered tumour for spatial snap-shot analysis of cell metabolism and phenotype in hypoxic gradients
The profound metabolic reprogramming that occurs in cancer cells has been investigated primarily in two-dimensional cell cultures, which fail to recapitulate spatial aspects of cell-to-cell interactions as well as tissue gradients present in three-dimensional (3D) tumours. Here, we describe an engin...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214740/ https://www.ncbi.nlm.nih.gov/pubmed/26595121 http://dx.doi.org/10.1038/nmat4482 |