Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways

Pattern recognition receptors (PRRs) and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary...

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Autores principales: Li, Yajuan, Li, Yuelong, Cao, Xiaocong, Jin, Xiangyu, Jin, Tengchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214946/
https://www.ncbi.nlm.nih.gov/pubmed/27721456
http://dx.doi.org/10.1038/cmi.2016.50
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author Li, Yajuan
Li, Yuelong
Cao, Xiaocong
Jin, Xiangyu
Jin, Tengchuan
author_facet Li, Yajuan
Li, Yuelong
Cao, Xiaocong
Jin, Xiangyu
Jin, Tengchuan
author_sort Li, Yajuan
collection PubMed
description Pattern recognition receptors (PRRs) and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.
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spelling pubmed-52149462017-01-13 Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways Li, Yajuan Li, Yuelong Cao, Xiaocong Jin, Xiangyu Jin, Tengchuan Cell Mol Immunol Review Pattern recognition receptors (PRRs) and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms. Nature Publishing Group 2017-01 2016-10-10 /pmc/articles/PMC5214946/ /pubmed/27721456 http://dx.doi.org/10.1038/cmi.2016.50 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Li, Yajuan
Li, Yuelong
Cao, Xiaocong
Jin, Xiangyu
Jin, Tengchuan
Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title_full Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title_fullStr Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title_full_unstemmed Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title_short Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
title_sort pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214946/
https://www.ncbi.nlm.nih.gov/pubmed/27721456
http://dx.doi.org/10.1038/cmi.2016.50
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