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Mediastinal seminoma associated with multilocular thymic cyst
An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215007/ https://www.ncbi.nlm.nih.gov/pubmed/28054283 http://dx.doi.org/10.1186/s40792-016-0278-7 |
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author | Inui, Masato Nitadori, Jun-ichi Tajima, Shogo Yoshioka, Takahusa Hiyama, Noriko Watadani, Takeyuki Shinozaki-Ushiku, Aya Nagayama, Kazuhiro Anraku, Masaki Sato, Masaaki Fukayama, Masashi Nakajima, Jun |
author_facet | Inui, Masato Nitadori, Jun-ichi Tajima, Shogo Yoshioka, Takahusa Hiyama, Noriko Watadani, Takeyuki Shinozaki-Ushiku, Aya Nagayama, Kazuhiro Anraku, Masaki Sato, Masaaki Fukayama, Masashi Nakajima, Jun |
author_sort | Inui, Masato |
collection | PubMed |
description | An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface. So, cysts were probably secondary changes caused by seminoma cells themselves or inflammatory stimulations. No invasion to adjacent structures was seen. After the surgery, testicular ultrasound imaging and abdominal, pelvic, and cerebral CT showed no apparent tumor or enlarged lymph nodes; however, an abnormal uptake in the right mesenteric lymph node was pointed out by (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scan. The patient received four courses of bleomycin, etoposide, and cisplatin (BEP) as adjuvant chemotherapy. Follow-up PET scan revealed no uptake in the right mesenteric lymph node. To date, no recurrence or metastasis has been identified for 16 months. |
format | Online Article Text |
id | pubmed-5215007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-52150072017-01-18 Mediastinal seminoma associated with multilocular thymic cyst Inui, Masato Nitadori, Jun-ichi Tajima, Shogo Yoshioka, Takahusa Hiyama, Noriko Watadani, Takeyuki Shinozaki-Ushiku, Aya Nagayama, Kazuhiro Anraku, Masaki Sato, Masaaki Fukayama, Masashi Nakajima, Jun Surg Case Rep Case Report An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. We performed total resection of the tumor through a median sternotomy. The pathological findings revealed seminoma, positive for c-kit stain, and multilocular thymic cysts. Cysts were lined by normal squamous epithelium and no seminoma cells were located on their surface. So, cysts were probably secondary changes caused by seminoma cells themselves or inflammatory stimulations. No invasion to adjacent structures was seen. After the surgery, testicular ultrasound imaging and abdominal, pelvic, and cerebral CT showed no apparent tumor or enlarged lymph nodes; however, an abnormal uptake in the right mesenteric lymph node was pointed out by (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scan. The patient received four courses of bleomycin, etoposide, and cisplatin (BEP) as adjuvant chemotherapy. Follow-up PET scan revealed no uptake in the right mesenteric lymph node. To date, no recurrence or metastasis has been identified for 16 months. Springer Berlin Heidelberg 2017-01-05 /pmc/articles/PMC5215007/ /pubmed/28054283 http://dx.doi.org/10.1186/s40792-016-0278-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Case Report Inui, Masato Nitadori, Jun-ichi Tajima, Shogo Yoshioka, Takahusa Hiyama, Noriko Watadani, Takeyuki Shinozaki-Ushiku, Aya Nagayama, Kazuhiro Anraku, Masaki Sato, Masaaki Fukayama, Masashi Nakajima, Jun Mediastinal seminoma associated with multilocular thymic cyst |
title | Mediastinal seminoma associated with multilocular thymic cyst |
title_full | Mediastinal seminoma associated with multilocular thymic cyst |
title_fullStr | Mediastinal seminoma associated with multilocular thymic cyst |
title_full_unstemmed | Mediastinal seminoma associated with multilocular thymic cyst |
title_short | Mediastinal seminoma associated with multilocular thymic cyst |
title_sort | mediastinal seminoma associated with multilocular thymic cyst |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215007/ https://www.ncbi.nlm.nih.gov/pubmed/28054283 http://dx.doi.org/10.1186/s40792-016-0278-7 |
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