Genomic Characterization of High-Count MBL Cases Indicates that Early Detection of Driver Mutations and Subclonal Expansion are Predictors of Adverse Clinical Outcome

High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic expansion of clonal B-cells in the peripheral blood without other manifestations of chronic lymphocytic leukemia (CLL). Yearly, 1% of MBLs evolve to CLL requiring therapy; thus being critical to understand the biologic events that d...

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Detalles Bibliográficos
Autores principales: Barrio, S., Shanafelt, T. D., Ojha, J., Chaffee, K. G., Secreto, C., Kortüm, K. M., Pathangey, S., Van-Dyke, D. L., Slager, S. L., Fonseca, R., Kay, N. E., Braggio, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215040/
https://www.ncbi.nlm.nih.gov/pubmed/27469216
http://dx.doi.org/10.1038/leu.2016.172

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