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Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Therapeutic monoclonal antibodies (mAbs) have heterogeneities in their structures. Multiple studies have reported that the variety of post-translational modifications could affect the pharmacokinetic profiles or pharmacological potencies of therapeutic mAbs. Taking into the account that the structur...

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Detalles Bibliográficos
Autores principales:	Otani, Yuki, Yonezawa, Atushi, Tsuda, Masahiro, Imai, Satoshi, Ikemi, Yasuaki, Nakagawa, Shunsaku, Omura, Tomohiro, Nakagawa, Takayuki, Yano, Ikuko, Matsubara, Kazuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215255/ https://www.ncbi.nlm.nih.gov/pubmed/28052138 http://dx.doi.org/10.1371/journal.pone.0169588

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