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Hepatic metastasis of thymoma: case report and immunohistochemical study
Thymomas are rare tumours characterised by their slow growth and capacity to invade directly by contiguity. While distant dissemination is infrequent, all sub-types of thymoma have the capacity to metastasise to extrathoracic organs. We present here the case of a female patient with a liver mass dis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cancer Intelligence
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215263/ https://www.ncbi.nlm.nih.gov/pubmed/28101136 http://dx.doi.org/10.3332/ecancer.2016.693 |
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author | Speisky, Daniela de Davila, María Teresa García Vigovich, Felix Mendez, Julian Maurette, Rafael Ejarque, Marcos García Spina, Juan Carlos Iotti, Alejandro Dezanzo, Pablo |
author_facet | Speisky, Daniela de Davila, María Teresa García Vigovich, Felix Mendez, Julian Maurette, Rafael Ejarque, Marcos García Spina, Juan Carlos Iotti, Alejandro Dezanzo, Pablo |
author_sort | Speisky, Daniela |
collection | PubMed |
description | Thymomas are rare tumours characterised by their slow growth and capacity to invade directly by contiguity. While distant dissemination is infrequent, all sub-types of thymoma have the capacity to metastasise to extrathoracic organs. We present here the case of a female patient with a liver mass discovered 13 years after the removal of a mediastinal thymoma and after ten years from thyroidectomy for papillary carcinoma. The histopathological study showed that the lesion contained an epithelial component, which was immunohistochemically positive for pankeratin. It was accompanied by numerous small lymphocytes testing positive for TdT, CD3, CD4, CD5, CD8, CD99, and CD43. The result was consistent with hepatic metastatic thymoma sub-type B1, according to the World Health Organisation classification (WHO). Our case highlights the importance of morphological and immunohistological examinations in the differential diagnosis of visceral masses in patients with a history of thymoma. Given the infrequency of its metastasis and the increased risk of developing other primary tumours that these patients have, these studies play a significant role. |
format | Online Article Text |
id | pubmed-5215263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Cancer Intelligence |
record_format | MEDLINE/PubMed |
spelling | pubmed-52152632017-01-18 Hepatic metastasis of thymoma: case report and immunohistochemical study Speisky, Daniela de Davila, María Teresa García Vigovich, Felix Mendez, Julian Maurette, Rafael Ejarque, Marcos García Spina, Juan Carlos Iotti, Alejandro Dezanzo, Pablo Ecancermedicalscience Case Report Thymomas are rare tumours characterised by their slow growth and capacity to invade directly by contiguity. While distant dissemination is infrequent, all sub-types of thymoma have the capacity to metastasise to extrathoracic organs. We present here the case of a female patient with a liver mass discovered 13 years after the removal of a mediastinal thymoma and after ten years from thyroidectomy for papillary carcinoma. The histopathological study showed that the lesion contained an epithelial component, which was immunohistochemically positive for pankeratin. It was accompanied by numerous small lymphocytes testing positive for TdT, CD3, CD4, CD5, CD8, CD99, and CD43. The result was consistent with hepatic metastatic thymoma sub-type B1, according to the World Health Organisation classification (WHO). Our case highlights the importance of morphological and immunohistological examinations in the differential diagnosis of visceral masses in patients with a history of thymoma. Given the infrequency of its metastasis and the increased risk of developing other primary tumours that these patients have, these studies play a significant role. Cancer Intelligence 2016-11-22 /pmc/articles/PMC5215263/ /pubmed/28101136 http://dx.doi.org/10.3332/ecancer.2016.693 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Speisky, Daniela de Davila, María Teresa García Vigovich, Felix Mendez, Julian Maurette, Rafael Ejarque, Marcos García Spina, Juan Carlos Iotti, Alejandro Dezanzo, Pablo Hepatic metastasis of thymoma: case report and immunohistochemical study |
title | Hepatic metastasis of thymoma: case report and immunohistochemical study |
title_full | Hepatic metastasis of thymoma: case report and immunohistochemical study |
title_fullStr | Hepatic metastasis of thymoma: case report and immunohistochemical study |
title_full_unstemmed | Hepatic metastasis of thymoma: case report and immunohistochemical study |
title_short | Hepatic metastasis of thymoma: case report and immunohistochemical study |
title_sort | hepatic metastasis of thymoma: case report and immunohistochemical study |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215263/ https://www.ncbi.nlm.nih.gov/pubmed/28101136 http://dx.doi.org/10.3332/ecancer.2016.693 |
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