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Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages

PURPOSE: Mutations in membrane frizzled-related protein (MFRP) are associated with nanophthalmia, hyperopia, foveoschisis, irregular patches of RPE atrophy, and optic disc drusen in humans. Mouse mfrp mutants show retinal degeneration but no change in eye size or refractive state. The goal of this w...

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Detalles Bibliográficos
Autores principales:	Collery, Ross F., Volberding, Peter J., Bostrom, Jonathan R., Link, Brian A., Besharse, Joseph C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215506/ https://www.ncbi.nlm.nih.gov/pubmed/28002843 http://dx.doi.org/10.1167/iovs.16-19593

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