Hallmarks of cancer and AU‐rich elements

Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU‐rich elements (AREs), cis‐acting mRNA decay determinants, play a major role in the posttranscriptional regulation of many ge...

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Detalles Bibliográficos
Autor principal: Khabar, Khalid S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2016
Materias:
Advanced Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215528/
https://www.ncbi.nlm.nih.gov/pubmed/27251431
http://dx.doi.org/10.1002/wrna.1368
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author Khabar, Khalid S. A.
author_facet Khabar, Khalid S. A.
author_sort Khabar, Khalid S. A.
collection PubMed
description Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU‐rich elements (AREs), cis‐acting mRNA decay determinants, play a major role in the posttranscriptional regulation of many genes involved in cancer processes. This review discusses the role of aberrant ARE‐mediated posttranscriptional processes in each of the hallmarks of cancer, including sustained cellular growth, resistance to apoptosis, angiogenesis, invasion, and metastasis. WIREs RNA 2017, 8:e1368. doi: 10.1002/wrna.1368 For further resources related to this article, please visit the WIREs website.
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spelling pubmed-52155282017-01-18 Hallmarks of cancer and AU‐rich elements Khabar, Khalid S. A. Wiley Interdiscip Rev RNA Advanced Reviews Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU‐rich elements (AREs), cis‐acting mRNA decay determinants, play a major role in the posttranscriptional regulation of many genes involved in cancer processes. This review discusses the role of aberrant ARE‐mediated posttranscriptional processes in each of the hallmarks of cancer, including sustained cellular growth, resistance to apoptosis, angiogenesis, invasion, and metastasis. WIREs RNA 2017, 8:e1368. doi: 10.1002/wrna.1368 For further resources related to this article, please visit the WIREs website. John Wiley & Sons, Inc. 2016-06-01 2017 /pmc/articles/PMC5215528/ /pubmed/27251431 http://dx.doi.org/10.1002/wrna.1368 Text en © 2016 The Authors. WIREs RNA published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Advanced Reviews
Khabar, Khalid S. A.
Hallmarks of cancer and AU‐rich elements
title Hallmarks of cancer and AU‐rich elements
title_full Hallmarks of cancer and AU‐rich elements
title_fullStr Hallmarks of cancer and AU‐rich elements
title_full_unstemmed Hallmarks of cancer and AU‐rich elements
title_short Hallmarks of cancer and AU‐rich elements
title_sort hallmarks of cancer and au‐rich elements
topic Advanced Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215528/
https://www.ncbi.nlm.nih.gov/pubmed/27251431
http://dx.doi.org/10.1002/wrna.1368
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