Anionic Oligothiophenes Compete for Binding of X‐34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain‐Derived Aβ

Deposits comprised of amyloid‐β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X‐34, a Con...

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Detalles Bibliográficos
Autores principales: Bäck, Marcus, Appelqvist, Hanna, LeVine, Harry, Nilsson, K. Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215536/
https://www.ncbi.nlm.nih.gov/pubmed/27767229
http://dx.doi.org/10.1002/chem.201604583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215536/
https://www.ncbi.nlm.nih.gov/pubmed/27767229
http://dx.doi.org/10.1002/chem.201604583

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