Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria

BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...

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Detalles Bibliográficos
Autores principales: Jeeyapant, Atthanee, Kingston, Hugh W., Plewes, Katherine, Maude, Richard J., Hanson, Josh, Herdman, M. Trent, Leopold, Stije J., Ngernseng, Thatsanun, Charunwatthana, Prakaykaew, Phu, Nguyen Hoan, Ghose, Aniruddha, Hasan, M. Mahtab Uddin, Fanello, Caterina I., Faiz, Md Abul, Hien, Tran Tinh, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215574/
https://www.ncbi.nlm.nih.gov/pubmed/28052109
http://dx.doi.org/10.1371/journal.pone.0169307

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