Cargando…

PCSK9 Inhibition With Monoclonal Antibodies: Modern Management of Hypercholesterolemia

Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and lipid‐modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary class of agents used for the treatment of hypercholesterolemia. Although statins are effective for many patients,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Matthew K., Santos, Raul D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Editor's choice: Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215586/ https://www.ncbi.nlm.nih.gov/pubmed/27195910 http://dx.doi.org/10.1002/jcph.766

Ejemplares similares

Monoclonal Antibodies in the Management of Familial Hypercholesterolemia: Focus on PCSK9 and ANGPTL3 Inhibitors
por: Pirillo, Angela, et al.
Publicado: (2021)

Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking
por: Acquaye‐Seedah, Edith, et al.
Publicado: (2018)

PCSK9 Antibodies for the Treatment of Hypercholesterolemia
por: Gouni-Berthold, Ioanna, et al.
Publicado: (2014)

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody
por: Hopkins, Paul N., et al.
Publicado: (2015)

PCSK9 Monoclonal Antibodies: An Overview
por: Kaddoura, Rasha, et al.
Publicado: (2020)

The Use of Monoclonal Antibody-Based Proprotein Convertase Subtilisin-Kexin Type 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia
por: Parikh, Riya R, et al.
Publicado: (2022)

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells
por: Schoeler, Katia, et al.
Publicado: (2019)

British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy
por: Grigoriadou, S, et al.
Publicado: (2022)

A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS‐activated cancer cells
por: Mori, Kazunori, et al.
Publicado: (2018)

Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy – a prospective, observational cohort study from the United Kingdom
por: Rice, T. F., et al.
Publicado: (2019)

Vimentin S‐glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro
por: Kaus‐Drobek, Magdalena, et al.
Publicado: (2020)

An easy‐to‐perform, culture‐free Campylobacter point‐of‐management assay for processing plant applications
por: Mason, M.G., et al.
Publicado: (2019)

Frequency and management of non‐obstetric fistula in the Democratic Republic of Congo: experience from the Fistula Care Plus project
por: Mpunga Mafu, Michel, et al.
Publicado: (2020)

Modelling the cost‐effectiveness of pulse oximetry in primary care management of acute respiratory infection in rural northern Thailand
por: Chew, Rusheng, et al.
Publicado: (2022)

The utility of the ‘Arable Weeds and Management in Europe’ database: Challenges and opportunities of combining weed survey data at a European scale
por: Metcalfe, Helen, et al.
Publicado: (2022)

microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production
por: Dong, Jianjie, et al.
Publicado: (2020)

The impact of a social network based intervention on self-management behaviours among patients with type 2 diabetes living in socioeconomically deprived neighbourhoods: a mixed methods approach
por: Vissenberg, Charlotte, et al.
Publicado: (2017)

PCSK9 Inhibitors for the Management of Mitotane-Induced Hypercholesterolemia in Adrenocortical Carcinoma
por: Aurora, John A, et al.
Publicado: (2021)

Cascading effects of composts and cover crops on soil chemistry, bacterial communities and the survival of foodborne pathogens
por: Devarajan, N., et al.
Publicado: (2021)

Antiplatelet Effects of PCSK9 Inhibitors in Primary Hypercholesterolemia
por: Pęczek, Piotr, et al.
Publicado: (2021)

Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia
por: Tomlinson, Brian, et al.
Publicado: (2021)

Notch signalling is a potential resistance mechanism of progenitor cells within patient‐derived prostate cultures following ROS‐inducing treatments
por: Packer, John R., et al.
Publicado: (2019)

Cross-Sectional and Cumulative Longitudinal Central Nervous System Penetration Effectiveness Scores Are Not Associated With Neurocognitive Impairment in a Well Treated Aging Human Immunodeficiency Virus-Positive Population in Switzerland
por: Santos, Galia M A, et al.
Publicado: (2019)

The Editors’ Choice
por: Ballas, Zuhair K.
Publicado: (2020)

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity
por: Vautier, Simon, et al.
Publicado: (2015)

Definition of the Spatial Propagator and Implications for Magnetic Field Properties
por: Edmondson, Justin K., et al.
Publicado: (2019)

How industrial bacterial cultures can be kept stable over time
por: Wassenaar, T.M., et al.
Publicado: (2020)

PCSK9 Inhibitors: What Lies Beyond Monoclonal Antibodies?
por: EBioMedicine
Publicado: (2015)

Met1-linked ubiquitination in immune signalling
por: Fiil, Berthe K, et al.
Publicado: (2014)

Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives
por: Catapano, Alberico Luigi, et al.
Publicado: (2017)

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions
por: Woodworth, Michael H, et al.
Publicado: (2019)

Pathogen–host reorganization during Chlamydia invasion revealed by cryo-electron tomography
por: Nans, Andrea, et al.
Publicado: (2014)

Complex genetic architecture of three‐dimensional craniofacial shape variation in domestic pigeons
por: Boer, Elena F., et al.
Publicado: (2021)

Carbamylation reduces the capacity of IgG for hexamerization and complement activation
por: Lubbers, R., et al.
Publicado: (2020)

Arthritis in systemic lupus erythematosus is characterized by local IL‐17A and IL‐6 expression in synovial fluid
por: Sippl, N., et al.
Publicado: (2021)

The sporadic nature of Legionella pneumophila, Legionella pneumophila Sg1 and Mycobacterium avium occurrence within residences and office buildings across 36 states in the United States
por: Donohue, M.J., et al.
Publicado: (2019)

A New Statistical Method for Estimating Usual Intakes of Nearly-Daily Consumed Foods and Nutrients Through Use of Only One 24-hour Dietary Recall
por: Luo, Hanqi, et al.
Publicado: (2019)

Effects of stably incorporated iron on protein phosphatase‐1 structure and activity
por: Salvi, Francesca, et al.
Publicado: (2018)

Factors Associated With Ventriculoperitoneal Shunt Placement in Patients With Cryptococcal Meningitis
por: Baddley, John W, et al.
Publicado: (2019)

Differential effects of Vav‐promoter‐driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis
por: Tuzlak, Selma, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pt1g99loirsb5kj8132khvui9d