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Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleos...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215604/ https://www.ncbi.nlm.nih.gov/pubmed/28101510 http://dx.doi.org/10.1155/2016/5959721 |
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author | Uchida, Chiharu |
author_facet | Uchida, Chiharu |
author_sort | Uchida, Chiharu |
collection | PubMed |
description | Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromosomes via histone modification, epigenetic changes, chromatin remodeling, and chromosome organization. Functional inactivation of pRB perturbs these cellular events and causes dysregulated cell growth and chromosome instability, which are hallmarks of cancer cells. The role of pRB in regulation of nucleosome/chromatin structures has been shown to link to tumor suppression. This review focuses on the ability of pRB to control nucleosome/chromatin structures via physical interactions with histone modifiers and chromatin factors and describes cancer therapies based on targeting these protein factors. |
format | Online Article Text |
id | pubmed-5215604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52156042017-01-18 Roles of pRB in the Regulation of Nucleosome and Chromatin Structures Uchida, Chiharu Biomed Res Int Review Article Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromosomes via histone modification, epigenetic changes, chromatin remodeling, and chromosome organization. Functional inactivation of pRB perturbs these cellular events and causes dysregulated cell growth and chromosome instability, which are hallmarks of cancer cells. The role of pRB in regulation of nucleosome/chromatin structures has been shown to link to tumor suppression. This review focuses on the ability of pRB to control nucleosome/chromatin structures via physical interactions with histone modifiers and chromatin factors and describes cancer therapies based on targeting these protein factors. Hindawi Publishing Corporation 2016 2016-12-22 /pmc/articles/PMC5215604/ /pubmed/28101510 http://dx.doi.org/10.1155/2016/5959721 Text en Copyright © 2016 Chiharu Uchida. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Uchida, Chiharu Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title | Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title_full | Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title_fullStr | Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title_full_unstemmed | Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title_short | Roles of pRB in the Regulation of Nucleosome and Chromatin Structures |
title_sort | roles of prb in the regulation of nucleosome and chromatin structures |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215604/ https://www.ncbi.nlm.nih.gov/pubmed/28101510 http://dx.doi.org/10.1155/2016/5959721 |
work_keys_str_mv | AT uchidachiharu rolesofprbintheregulationofnucleosomeandchromatinstructures |