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Nutlin‐3a selects for cells harbouring TP 53 mutations

TP53 mutations occur in half of all human tumours. Mutagen‐induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock‐in (Hupki) mouse embryo fibroblast (HUF) immortalisation assay (HIMA). TP53 mutations arise in up to 30% of mutagen‐treated, immortalised HUFs; howeve...

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Detalles Bibliográficos
Autores principales:	Kucab, Jill E., Hollstein, Monica, Arlt, Volker M., Phillips, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Molecular Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215675/ https://www.ncbi.nlm.nih.gov/pubmed/27813088 http://dx.doi.org/10.1002/ijc.30504

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