Cargando…
The bacterial dicarboxylate transporter, VcINDY, uses a two-domain elevator-type mechanism
Secondary transporters use alternating access mechanisms to couple uphill substrate movement to downhill ion flux. Most known transporters utilize a “rocking bundle” motion, where the protein moves around an immobile substrate binding site. However, the glutamate transporter homolog, Glt(Ph), transl...
Autores principales: | Mulligan, Christopher, Fenollar-Ferrer, Cristina, Fitzgerald, Gabriel A., Vergara-Jaque, Ariela, Kaufmann, Desirée, Li, Yan, Forrest, Lucy R., Mindell, Joseph A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215794/ https://www.ncbi.nlm.nih.gov/pubmed/26828963 http://dx.doi.org/10.1038/nsmb.3166 |
Ejemplares similares
-
Structural basis of ion – substrate coupling in the Na(+)-dependent dicarboxylate transporter VcINDY
por: Sauer, David B., et al.
Publicado: (2022) -
Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY
por: Sampson, Connor D. D., et al.
Publicado: (2021) -
Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms
por: Vergara-Jaque, Ariela, et al.
Publicado: (2015) -
Family resemblances: A common fold for some dimeric ion-coupled secondary transporters
por: Vergara-Jaque, Ariela, et al.
Publicado: (2015) -
Functional characterization of a Na(+)-dependent dicarboxylate transporter from Vibrio cholerae
por: Mulligan, Christopher, et al.
Publicado: (2014)