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New insights into the biosynthesis of fosfazinomycin

The biosynthetic origin of a unique hydrazide moiety in the phosphonate natural product fosfazinomycin is unknown. This study presents the activities of five proteins encoded in its gene cluster. The flavin-dependent oxygenase FzmM catalyses the oxidation of l-Asp to N-hydroxy-Asp. When FzmL is adde...

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Detalles Bibliográficos
Autores principales:	Huang, Zedu, Wang, Kwo-Kwang Abraham, van der Donk, Wilfred A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215806/ https://www.ncbi.nlm.nih.gov/pubmed/28070267 http://dx.doi.org/10.1039/c6sc01389a

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