Cargando…

HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma

Conventional cytotoxic therapies for synovial sarcoma provide limited benefit, and no drugs specifically targeting its driving SS18-SSX fusion oncoprotein are currently available. Patients remain at high risk for early and late metastasis. A high-throughput drug screen consisting of over 900 tool co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laporte, Aimée N., Barrott, Jared J., Yao, Ren Jie, Poulin, Neal M., Brodin, Bertha A., Jones, Kevin B., Underhill, T. Michael, Nielsen, Torsten O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215898/ https://www.ncbi.nlm.nih.gov/pubmed/28056055 http://dx.doi.org/10.1371/journal.pone.0169407

Ejemplares similares

Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma
por: Nguyen, Anne, et al.
Publicado: (2009)

Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay
por: Laporte, Aimée N., et al.
Publicado: (2016)

Oncostatin M Receptor as a Therapeutic Target for Radioimmune Therapy in Synovial Sarcoma
por: McCollum, Sarah, et al.
Publicado: (2022)

Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma
por: Kirkham, Matthew, et al.
Publicado: (2020)

Epigenetic Changes at the Birc5 Promoter Induced by YM155 in Synovial Sarcoma
por: Mika, Aleksander, et al.
Publicado: (2019)

HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
por: Cooley, Christina, et al.
Publicado: (2021)

Formulation, Characterization, and In Vitro/In Vivo Efficacy Studies of a Novel Liposomal Drug Delivery System of Amphiphilic Jaspine B for Treatment of Synovial Sarcoma
por: Khajeh pour, Sana, et al.
Publicado: (2022)

Modeling synovial sarcoma metastasis in the mouse: PI3′-lipid signaling and inflammation
por: Barrott, Jared J., et al.
Publicado: (2016)

Vorinostat synergizes with ridaforolimus and abrogates the ridaforolimus-induced activation of AKT in synovial sarcoma cells
por: Morgan, Sherif S, et al.
Publicado: (2014)

Sarcoma–The standard-bearer in cancer discovery
por: Potter, Jared W., et al.
Publicado: (2018)

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
por: Bolden, J E, et al.
Publicado: (2013)

Intraosseous Synovial Sarcoma of the Proximal Tibia
por: Beck, Sarah E., et al.
Publicado: (2011)

Expanding the Use of an SS18-SSX Antibody for Molecular Assays in Synovial Sarcoma
por: Raquib, Ainiah Rushdiana, et al.
Publicado: (2022)

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability
por: Benabdallah, Nezha S., et al.
Publicado: (2023)

GI Synovial Sarcomas
por: Sinniah, Rajeev Palar, et al.
Publicado: (2012)

Synovial sarcoma of the mandible
por: Khalili, Maryam, et al.
Publicado: (2012)

Pulmonary synovial sarcoma
por: Gupta, Ankit, et al.
Publicado: (2018)

Synovial Sarcoma of the Hand
por: Ohan, Hovsep, et al.
Publicado: (2020)

Synovial-cell sarcoma
por: Nugud, Ahmed, et al.
Publicado: (2019)

Primary Cutaneous Synovial Sarcoma: An Extremely Rare Report of Superficial Synovial Sarcoma
por: Namazi, Nastaran, et al.
Publicado: (2016)

Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma
por: Lanzi, Cinzia, et al.
Publicado: (2021)

Variability of pro-apoptotic properties of cyclooxygenase-2 inhibitors in rheumatoid synovial fibroblasts and cancer cell lines
por: Kawai, S, et al.
Publicado: (2003)

8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1
por: Zhang, Qiting, et al.
Publicado: (2021)

Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102
por: Brashears, Caitlyn B., et al.
Publicado: (2022)

Synovial Sarcoma of the Abdominal Wall
por: Hale, J. E., et al.
Publicado: (1970)

Primary Mediastinal Synovial Sarcoma
por: Jeganathan, Reubendra, et al.
Publicado: (2007)

Primary renal synovial sarcoma
por: Grampurohit, Vandana U., et al.
Publicado: (2011)

Primary Renal Synovial Sarcoma
por: Gulum, Mehmet, et al.
Publicado: (2011)

Synovial Sarcoma of the Thyroid Gland
por: Ryu, Chang Hwan, et al.
Publicado: (2011)

Primary Synovial Sarcoma of the Kidney
por: Kawahara, Takashi, et al.
Publicado: (2009)

Primary renal synovial sarcoma
por: Bakhshi, Girish D., et al.
Publicado: (2012)

Primary synovial sarcoma of lung
por: Devleena,, et al.
Publicado: (2014)

Primary Synovial Sarcoma of Lung
por: Cabuk, Devrim, et al.
Publicado: (2014)

Primary Intracranial Synovial Sarcoma
por: Patel, Mohit, et al.
Publicado: (2016)

Synovial Sarcoma of the Abdominal Wall
por: McNeill, Jeanine, et al.
Publicado: (2015)

Primary Synovial Sarcoma of the Lung
por: Boulter, Daniel J., et al.
Publicado: (2015)

Metastatic biomarkers in synovial sarcoma
por: de Necochea-Campion, Rosalia, et al.
Publicado: (2017)

Primary Synovial Sarcoma of the Orbit
por: Xu, Pei, et al.
Publicado: (2017)

Synovial Sarcoma of Ethmoidal Sinus
por: Dhiman, Sapna, et al.
Publicado: (2021)

Primary mediastinal synovial sarcomas
por: Syred, Katherine, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1on364gqhdp4pq67o3a0n5tc0g