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L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes

Aconitine (ACO) is well-known for causing lethal ventricular tachyarrhythmias. While cardiac Na(+) channel opening during repolarization has long been documented in animal cardiac myocytes, the cellular effects and mechanism of ACO in human remain unexplored. This study aimed to assess the proarrhyt...

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Detalles Bibliográficos
Autores principales:	Wu, Jianjun, Wang, Xiangchong, Chung, Ying Ying, Koh, Cai Hong, Liu, Zhenfeng, Guo, Huicai, Yuan, Qiang, Wang, Chuan, Su, Suwen, Wei, Heming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215924/ https://www.ncbi.nlm.nih.gov/pubmed/28056022 http://dx.doi.org/10.1371/journal.pone.0168435

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