Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation

The forelimbs and hindlimbs of vertebrates are bilaterally symmetric. The mechanisms that ensure symmetric limb formation are unknown but they can be disrupted in disease. In Holt-Oram Syndrome (HOS), caused by mutations in TBX5, affected individuals have left-biased upper/forelimb defects. We demon...

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Detalles Bibliográficos
Autores principales: Sulaiman, Fatima A., Nishimoto, Satoko, Murphy, George R. F., Kucharska, Anna, Butterfield, Natalie C., Newbury-Ecob, Ruth, Logan, Malcolm P. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215935/
https://www.ncbi.nlm.nih.gov/pubmed/27992425
http://dx.doi.org/10.1371/journal.pgen.1006521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215935/
https://www.ncbi.nlm.nih.gov/pubmed/27992425
http://dx.doi.org/10.1371/journal.pgen.1006521

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