The role of break-induced replication in large-scale expansions of (CAG)(n)•(CTG)(n) repeats

Expansions of (CAG)(n)•(CTG)(n) trinucleotide repeats are responsible for over a dozen neuromuscular and neurodegenerative disorders. Large-scale expansions are typical for human pedigrees and may be explained by iterative small-scale events such as strand slippage during replication or repair DNA s...

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Detalles Bibliográficos
Autores principales: Kim, Jane C., Harris, Samantha T., Dinter, Teresa, Shah, Kartik A., Mirkin, Sergei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215974/
https://www.ncbi.nlm.nih.gov/pubmed/27918542
http://dx.doi.org/10.1038/nsmb.3334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215974/
https://www.ncbi.nlm.nih.gov/pubmed/27918542
http://dx.doi.org/10.1038/nsmb.3334

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