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The role of break-induced replication in large-scale expansions of (CAG)(n)•(CTG)(n) repeats
Expansions of (CAG)(n)•(CTG)(n) trinucleotide repeats are responsible for over a dozen neuromuscular and neurodegenerative disorders. Large-scale expansions are typical for human pedigrees and may be explained by iterative small-scale events such as strand slippage during replication or repair DNA s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215974/ https://www.ncbi.nlm.nih.gov/pubmed/27918542 http://dx.doi.org/10.1038/nsmb.3334 |