Cargando…

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

Autism spectrum disorders (ASD) are common, complex and heterogeneous neurodevelopmental disorders. Cellular and molecular mechanisms responsible for ASD pathogenesis have been proposed based on genetic studies, brain pathology, and imaging, but a major impediment to testing ASD hypotheses is the la...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marchetto, Maria C., Belinson, Haim, Tian, Yuan, Freitas, Beatriz C., Fu, Chen, Vadodaria, Krishna, Beltrao-Braga, Patricia, Trujillo, Cleber A., Mendes, Ana P.D., Padmanabhan, Krishnan, Nunez, Yanelli, Ou, Jing, Ghosh, Himanish, Wright, Rebecca, Brennand, Kristen, Pierce, Karen, Eichenfield, Lawrence, Pramparo, Tiziano, Eyler, Lisa, Barnes, Cynthia C., Courchesne, Eric, Geschwind, Daniel H., Gage, Fred H., Wynshaw-Boris, Anthony, Muotri, Alysson R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215991/ https://www.ncbi.nlm.nih.gov/pubmed/27378147 http://dx.doi.org/10.1038/mp.2016.95

Ejemplares similares

Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages
por: Chow, Maggie L., et al.
Publicado: (2012)

Transcriptional Signature and Memory Retention of Human-Induced Pluripotent Stem Cells
por: Marchetto, Maria C. N., et al.
Publicado: (2009)

L1 retrotransposition in neurons is modulated by MeCP2
por: Muotri, Alysson R., et al.
Publicado: (2010)

Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers
por: Pramparo, Tiziano, et al.
Publicado: (2015)

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
por: Vadodaria, Krishna C., et al.
Publicado: (2018)

Prediction of response to drug therapy in psychiatric disorders
por: Stern, Shani, et al.
Publicado: (2018)

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
por: Marchetto, Maria C, et al.
Publicado: (2019)

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes
por: Lombardo, Michael V., et al.
Publicado: (2018)

Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes
por: Vadodaria, Krishna C., et al.
Publicado: (2021)

The ASD Living Biology: from cell proliferation to clinical phenotype
por: Courchesne, Eric, et al.
Publicado: (2018)

Brain organoids and insights on human evolution
por: Muotri, Alysson R.
Publicado: (2019)

Interchromosomal translocation in neural progenitor cells exposed to L1 retrotransposition
por: Muotri, Alysson R.
Publicado: (2023)

Personal victimization experiences of autistic and non-autistic children
por: Libster, Natalie, et al.
Publicado: (2022)

Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids
por: Wu, Wei, et al.
Publicado: (2020)

Sex differences in friendships and loneliness in autistic and non-autistic children across development
por: Libster, Natalie, et al.
Publicado: (2023)

Hierarchical cortical transcriptome disorganization in autism
por: Lombardo, Michael V., et al.
Publicado: (2017)

Advancing preclinical models of psychiatric disorders with human brain organoid cultures
por: Dixon, Thomas Anthony, et al.
Publicado: (2022)

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice
por: Moore, Spencer M., et al.
Publicado: (2019)

A perturbed gene network containing PI3K/AKT, RAS/ERK, WNT/β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity
por: Gazestani, Vahid H., et al.
Publicado: (2019)

Transposable Elements, Inflammation, and Neurological Disease
por: Saleh, Aurian, et al.
Publicado: (2019)

Editorial: Brain Organoids: Modeling in Neuroscience
por: Bordoni, Matteo, et al.
Publicado: (2020)

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder
por: Lombardo, M V, et al.
Publicado: (2018)

Systematic optimization of human pluripotent stem cells media using Design of Experiments
por: Marinho, Paulo A., et al.
Publicado: (2015)

Using developmental regression to reorganize the clinical importance of autistic atypicalities
por: Gagnon, David, et al.
Publicado: (2022)

Alternative Splicing Events Identified in Human Embryonic Stem Cells and Neural Progenitors
por: Yeo, Gene W, et al.
Publicado: (2007)

Atypical genomic cortical patterning in autism with poor early language outcome
por: Lombardo, Michael V., et al.
Publicado: (2021)

Differential LINE-1 regulation in pluripotent stem cells of humans and other great apes
por: Marchetto, Maria C. N., et al.
Publicado: (2013)

Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties
por: Lombardo, Michael V, et al.
Publicado: (2019)

Global Developmental Gene Expression and Pathway Analysis of Normal Brain Development and Mouse Models of Human Neuronal Migration Defects
por: Pramparo, Tiziano, et al.
Publicado: (2011)

Recent advancements and future requirements in vascularization of cortical organoids
por: LaMontagne, Erin, et al.
Publicado: (2022)

Editorial: Advances in iPSC technology for disease modeling and therapeutic applications
por: Wattanapanitch, Methichit, et al.
Publicado: (2023)

Autism Voices: A novel method to access first-person perspective of autistic youth
por: Courchesne, Valérie, et al.
Publicado: (2021)

Autistic children at risk of being underestimated: school-based pilot study of a strength-informed assessment
por: Courchesne, Valérie, et al.
Publicado: (2015)

Positive, negative, neutral—or unknown? The perceived valence of emotions expressed by young autistic children in a novel context suited to autism
por: Jacques, Claudine, et al.
Publicado: (2022)

Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism
por: Lombardo, Michael V., et al.
Publicado: (2021)

Autistic Children
por: Kanjilal, G. C.
Publicado: (1971)

Impact of alcohol exposure on neural development and network formation in human cortical organoids
por: Adams, Jason W., et al.
Publicado: (2022)

What interests young autistic children? An exploratory study of object exploration and repetitive behavior
por: Jacques, Claudine, et al.
Publicado: (2018)

Increasing the resolution of the adult neurogenesis picture
por: Lacar, Benjamin, et al.
Publicado: (2014)

Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
por: Trujillo, Cleber A, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7kvpv0e6h0570s8o28mde1ek8b