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Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

The Mon1–Ccz1 complex (MC1) is the guanine nucleotide exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 and is required for endosomal maturation and fusion at the vacuole/lysosome. Here we present the overall architecture of MC1 from Chaetomium thermophilum, and in combining biochemical studies and...

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Detalles Bibliográficos
Autores principales:	Kiontke, Stephan, Langemeyer, Lars, Kuhlee, Anne, Schuback, Saskia, Raunser, Stefan, Ungermann, Christian, Kümmel, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216073/ https://www.ncbi.nlm.nih.gov/pubmed/28051187 http://dx.doi.org/10.1038/ncomms14034

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