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PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

Non-homologous end-joining (NHEJ) is the most prominent DNA double strand break (DSB) repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which shares structural similarity with known NHEJ factors—XRCC4 and XLF. Here we report that PAXX is dispensable for physiological NHEJ in otherwi...

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Detalles Bibliográficos
Autores principales:	Liu, Xiangyu, Shao, Zhengping, Jiang, Wenxia, Lee, Brian J., Zha, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216128/ https://www.ncbi.nlm.nih.gov/pubmed/28051062 http://dx.doi.org/10.1038/ncomms13816

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