Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia

An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced re...

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Autores principales: Tsuda, Shin-ichi, Konishi, Kazunori, Otoda, Toshiki, Nagai, Takako, Takeda-Watanabe, Ai, Kanasaki, Megumi, Kitada, Munehiro, Nakagawa, Atsushi, Nishizawa, Makoto, Kanasaki, Keizo, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216145/
https://www.ncbi.nlm.nih.gov/pubmed/27904111
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author Tsuda, Shin-ichi
Konishi, Kazunori
Otoda, Toshiki
Nagai, Takako
Takeda-Watanabe, Ai
Kanasaki, Megumi
Kitada, Munehiro
Nakagawa, Atsushi
Nishizawa, Makoto
Kanasaki, Keizo
Koya, Daisuke
author_facet Tsuda, Shin-ichi
Konishi, Kazunori
Otoda, Toshiki
Nagai, Takako
Takeda-Watanabe, Ai
Kanasaki, Megumi
Kitada, Munehiro
Nakagawa, Atsushi
Nishizawa, Makoto
Kanasaki, Keizo
Koya, Daisuke
author_sort Tsuda, Shin-ichi
collection PubMed
description An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced restoration of a blunted HPA axis by avoiding hypoglycemia with the use of the DPP-4 inhibitor sitagliptin.
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spelling pubmed-52161452017-01-09 Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia Tsuda, Shin-ichi Konishi, Kazunori Otoda, Toshiki Nagai, Takako Takeda-Watanabe, Ai Kanasaki, Megumi Kitada, Munehiro Nakagawa, Atsushi Nishizawa, Makoto Kanasaki, Keizo Koya, Daisuke Intern Med Case Report An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced restoration of a blunted HPA axis by avoiding hypoglycemia with the use of the DPP-4 inhibitor sitagliptin. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216145/ /pubmed/27904111 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tsuda, Shin-ichi
Konishi, Kazunori
Otoda, Toshiki
Nagai, Takako
Takeda-Watanabe, Ai
Kanasaki, Megumi
Kitada, Munehiro
Nakagawa, Atsushi
Nishizawa, Makoto
Kanasaki, Keizo
Koya, Daisuke
Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title_full Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title_fullStr Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title_full_unstemmed Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title_short Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia
title_sort restoration of the hypothalamic-pituitary-adrenal response to hypoglycemia in type 2 diabetes by avoiding chronic hypoglycemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216145/
https://www.ncbi.nlm.nih.gov/pubmed/27904111
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