Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis

We herein report two cases of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA)-related nephritis in infectious endocarditis. In both cases, the patients were middle-aged men with proteinuria and hematuria, hypoalbuminemia, decreased kidney function, anemia, elevated C-reactive protein (C...

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Autores principales: Hirai, Kazuya, Miura, Naoto, Yoshino, Masabumi, Miyamoto, Kanyu, Nobata, Hironobu, Nagai, Takuhito, Suzuki, Keisuke, Banno, Shogo, Imai, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216148/
https://www.ncbi.nlm.nih.gov/pubmed/27904114
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author Hirai, Kazuya
Miura, Naoto
Yoshino, Masabumi
Miyamoto, Kanyu
Nobata, Hironobu
Nagai, Takuhito
Suzuki, Keisuke
Banno, Shogo
Imai, Hirokazu
author_facet Hirai, Kazuya
Miura, Naoto
Yoshino, Masabumi
Miyamoto, Kanyu
Nobata, Hironobu
Nagai, Takuhito
Suzuki, Keisuke
Banno, Shogo
Imai, Hirokazu
author_sort Hirai, Kazuya
collection PubMed
description We herein report two cases of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA)-related nephritis in infectious endocarditis. In both cases, the patients were middle-aged men with proteinuria and hematuria, hypoalbuminemia, decreased kidney function, anemia, elevated C-reactive protein (CRP) levels, and PR3-ANCA positivity. Each had bacteremia, due to Enterococcus faecium in one and Streptococcus bovis in the other. One patient received aortic valve replacement therapy for aortic regurgitation with vegetation, and the other underwent tricuspid valve replacement therapy and closure of a ventricular septic defect to treat tricuspid regurgitation with vegetation. These patients' urinary abnormalities and PR3-ANCA titers improved at 6 months after surgery following antibiotic treatment without steroid therapy.
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spelling pubmed-52161482017-01-09 Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis Hirai, Kazuya Miura, Naoto Yoshino, Masabumi Miyamoto, Kanyu Nobata, Hironobu Nagai, Takuhito Suzuki, Keisuke Banno, Shogo Imai, Hirokazu Intern Med Case Report We herein report two cases of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA)-related nephritis in infectious endocarditis. In both cases, the patients were middle-aged men with proteinuria and hematuria, hypoalbuminemia, decreased kidney function, anemia, elevated C-reactive protein (CRP) levels, and PR3-ANCA positivity. Each had bacteremia, due to Enterococcus faecium in one and Streptococcus bovis in the other. One patient received aortic valve replacement therapy for aortic regurgitation with vegetation, and the other underwent tricuspid valve replacement therapy and closure of a ventricular septic defect to treat tricuspid regurgitation with vegetation. These patients' urinary abnormalities and PR3-ANCA titers improved at 6 months after surgery following antibiotic treatment without steroid therapy. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216148/ /pubmed/27904114 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hirai, Kazuya
Miura, Naoto
Yoshino, Masabumi
Miyamoto, Kanyu
Nobata, Hironobu
Nagai, Takuhito
Suzuki, Keisuke
Banno, Shogo
Imai, Hirokazu
Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title_full Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title_fullStr Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title_full_unstemmed Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title_short Two Cases of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA)-related Nephritis in Infectious Endocarditis
title_sort two cases of proteinase 3-anti-neutrophil cytoplasmic antibody (pr3-anca)-related nephritis in infectious endocarditis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216148/
https://www.ncbi.nlm.nih.gov/pubmed/27904114
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