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Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases
Nilotinib is a selective tyrosine kinase inhibitor for the treatment of Philadelphia chromosome-positive leukemias. An elevation of the pancreatic enzyme level is one of the major adverse events associated with nilotinib, but whether or not nilotinib induces symptomatic pancreatitis remains to be el...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216150/ https://www.ncbi.nlm.nih.gov/pubmed/27904116 |
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author | Yamada, Toshiki Nannya, Yasuhito Shimizu, Masahito Seishima, Mitsuru Tsurumi, Hisashi |
author_facet | Yamada, Toshiki Nannya, Yasuhito Shimizu, Masahito Seishima, Mitsuru Tsurumi, Hisashi |
author_sort | Yamada, Toshiki |
collection | PubMed |
description | Nilotinib is a selective tyrosine kinase inhibitor for the treatment of Philadelphia chromosome-positive leukemias. An elevation of the pancreatic enzyme level is one of the major adverse events associated with nilotinib, but whether or not nilotinib induces symptomatic pancreatitis remains to be elucidated. The cases of two chronic myeloid leukemia patients treated with nilotinib who developed symptomatic acute pancreatitis on the third and fifth day of nilotinib administration are herein presented. Since both patients had no other etiologies for pancreatitis, nilotinib was considered to be the causal agent. The withdrawal of nilotinib resulted in a prompt recovery. These cases underline the importance of recognizing pancreatitis as a possible adverse event associated with nilotinib. |
format | Online Article Text |
id | pubmed-5216150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-52161502017-01-09 Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases Yamada, Toshiki Nannya, Yasuhito Shimizu, Masahito Seishima, Mitsuru Tsurumi, Hisashi Intern Med Case Report Nilotinib is a selective tyrosine kinase inhibitor for the treatment of Philadelphia chromosome-positive leukemias. An elevation of the pancreatic enzyme level is one of the major adverse events associated with nilotinib, but whether or not nilotinib induces symptomatic pancreatitis remains to be elucidated. The cases of two chronic myeloid leukemia patients treated with nilotinib who developed symptomatic acute pancreatitis on the third and fifth day of nilotinib administration are herein presented. Since both patients had no other etiologies for pancreatitis, nilotinib was considered to be the causal agent. The withdrawal of nilotinib resulted in a prompt recovery. These cases underline the importance of recognizing pancreatitis as a possible adverse event associated with nilotinib. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216150/ /pubmed/27904116 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Yamada, Toshiki Nannya, Yasuhito Shimizu, Masahito Seishima, Mitsuru Tsurumi, Hisashi Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title | Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title_full | Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title_fullStr | Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title_full_unstemmed | Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title_short | Symptomatic Acute Pancreatitis Induced by Nilotinib: A Report of Two Cases |
title_sort | symptomatic acute pancreatitis induced by nilotinib: a report of two cases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216150/ https://www.ncbi.nlm.nih.gov/pubmed/27904116 |
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