Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection

A 41-year-old man was referred to our hospital for treatment of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and co...

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Autores principales: Saburi, Masuho, Ogata, Masao, Satou, Takako, Yoshida, Natsumi, Nagamatsu, Kentaro, Nashimoto, Yuko, Moroga, Yui, Takano, Kuniko, Kohno, Kazuhiro, Shirao, Kuniaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216151/
https://www.ncbi.nlm.nih.gov/pubmed/27904117
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author Saburi, Masuho
Ogata, Masao
Satou, Takako
Yoshida, Natsumi
Nagamatsu, Kentaro
Nashimoto, Yuko
Moroga, Yui
Takano, Kuniko
Kohno, Kazuhiro
Shirao, Kuniaki
author_facet Saburi, Masuho
Ogata, Masao
Satou, Takako
Yoshida, Natsumi
Nagamatsu, Kentaro
Nashimoto, Yuko
Moroga, Yui
Takano, Kuniko
Kohno, Kazuhiro
Shirao, Kuniaki
author_sort Saburi, Masuho
collection PubMed
description A 41-year-old man was referred to our hospital for treatment of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and cord blood stem cell transplantation (CBT) was performed. The EBV-DNA levels in the blood fell below the limit of detection. His lymphoma relapsed on Day 165 with the appearance of eruptions, which disappeared after the withdrawal of tacrolimus. One year after transplantation, there were no signs of recurrence. This encouraging result suggests that CBT should be considered for adult cases of CAEBV with aggressive clinical manifestations.
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spelling pubmed-52161512017-01-09 Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection Saburi, Masuho Ogata, Masao Satou, Takako Yoshida, Natsumi Nagamatsu, Kentaro Nashimoto, Yuko Moroga, Yui Takano, Kuniko Kohno, Kazuhiro Shirao, Kuniaki Intern Med Case Report A 41-year-old man was referred to our hospital for treatment of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Chronic active Epstein-Barr virus (CAEBV) was diagnosed based on the findings of elevated EBV antibody titers and positive EBV-DNA in the peripheral blood, and cord blood stem cell transplantation (CBT) was performed. The EBV-DNA levels in the blood fell below the limit of detection. His lymphoma relapsed on Day 165 with the appearance of eruptions, which disappeared after the withdrawal of tacrolimus. One year after transplantation, there were no signs of recurrence. This encouraging result suggests that CBT should be considered for adult cases of CAEBV with aggressive clinical manifestations. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216151/ /pubmed/27904117 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saburi, Masuho
Ogata, Masao
Satou, Takako
Yoshida, Natsumi
Nagamatsu, Kentaro
Nashimoto, Yuko
Moroga, Yui
Takano, Kuniko
Kohno, Kazuhiro
Shirao, Kuniaki
Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title_full Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title_fullStr Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title_full_unstemmed Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title_short Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection
title_sort successful cord blood stem cell transplantation for an adult case of chronic active epstein-barr virus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216151/
https://www.ncbi.nlm.nih.gov/pubmed/27904117
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