Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease

We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia...

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Autores principales: Kitazawa, Atsushi, Misawa, Hideo, Nagahori, Katsuhiro, Koda, Ryo, Yoshino, Atsunori, Kawamoto, Shinya, Takeda, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216152/
https://www.ncbi.nlm.nih.gov/pubmed/27904118
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author Kitazawa, Atsushi
Misawa, Hideo
Nagahori, Katsuhiro
Koda, Ryo
Yoshino, Atsunori
Kawamoto, Shinya
Takeda, Tetsuro
author_facet Kitazawa, Atsushi
Misawa, Hideo
Nagahori, Katsuhiro
Koda, Ryo
Yoshino, Atsunori
Kawamoto, Shinya
Takeda, Tetsuro
author_sort Kitazawa, Atsushi
collection PubMed
description We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia (52.1%), prolonged activated partial thromboplastin time (APTT) (98 s), PT (84 s), a factor V (FV) activity of <3%, and an FV inhibitor level of 6 Bethesda units/mL. After administration of prednisolone was started, his coagulation findings improved. However, his renal failure progressed, and he ultimately required chronic hemodialysis. This is the first case of AFVIs in a patient starting hemodialysis for end-stage renal disease.
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spelling pubmed-52161522017-01-09 Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease Kitazawa, Atsushi Misawa, Hideo Nagahori, Katsuhiro Koda, Ryo Yoshino, Atsunori Kawamoto, Shinya Takeda, Tetsuro Intern Med Case Report We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia (52.1%), prolonged activated partial thromboplastin time (APTT) (98 s), PT (84 s), a factor V (FV) activity of <3%, and an FV inhibitor level of 6 Bethesda units/mL. After administration of prednisolone was started, his coagulation findings improved. However, his renal failure progressed, and he ultimately required chronic hemodialysis. This is the first case of AFVIs in a patient starting hemodialysis for end-stage renal disease. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216152/ /pubmed/27904118 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kitazawa, Atsushi
Misawa, Hideo
Nagahori, Katsuhiro
Koda, Ryo
Yoshino, Atsunori
Kawamoto, Shinya
Takeda, Tetsuro
Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title_full Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title_fullStr Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title_full_unstemmed Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title_short Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
title_sort acquired factor v inhibitors in a patient with end-stage renal disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216152/
https://www.ncbi.nlm.nih.gov/pubmed/27904118
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