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An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing
Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked lo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216153/ https://www.ncbi.nlm.nih.gov/pubmed/27904119 |
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author | Ito, Hisashi Kamei, Tetsumasa Odake, Sanae Nakano, Masayuki Okeda, Riki Kohriki, Shunsaku Kawachi, Jun Onders, Raymond P. Yoshii, Fumihito |
author_facet | Ito, Hisashi Kamei, Tetsumasa Odake, Sanae Nakano, Masayuki Okeda, Riki Kohriki, Shunsaku Kawachi, Jun Onders, Raymond P. Yoshii, Fumihito |
author_sort | Ito, Hisashi |
collection | PubMed |
description | Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm. However, no infiltration of inflammatory cells was detected. Our findings suggest that full-time DP might not cause severe damage to adjacent diaphragm tissue. |
format | Online Article Text |
id | pubmed-5216153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-52161532017-01-09 An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing Ito, Hisashi Kamei, Tetsumasa Odake, Sanae Nakano, Masayuki Okeda, Riki Kohriki, Shunsaku Kawachi, Jun Onders, Raymond P. Yoshii, Fumihito Intern Med Case Report Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm. However, no infiltration of inflammatory cells was detected. Our findings suggest that full-time DP might not cause severe damage to adjacent diaphragm tissue. The Japanese Society of Internal Medicine 2016-12-01 /pmc/articles/PMC5216153/ /pubmed/27904119 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Ito, Hisashi Kamei, Tetsumasa Odake, Sanae Nakano, Masayuki Okeda, Riki Kohriki, Shunsaku Kawachi, Jun Onders, Raymond P. Yoshii, Fumihito An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title | An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title_full | An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title_fullStr | An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title_full_unstemmed | An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title_short | An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing |
title_sort | autopsy case of amyotrophic lateral sclerosis with diaphragm pacing |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216153/ https://www.ncbi.nlm.nih.gov/pubmed/27904119 |
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