M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccinat...

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Detalles Bibliográficos
Autores principales: Sato, Yota, Fujimura, Taku, Furudate, Sadanori, Kakizaki, Aya, Iizawa, Osamu, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216204/
https://www.ncbi.nlm.nih.gov/pubmed/28101015
http://dx.doi.org/10.1159/000447709
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author Sato, Yota
Fujimura, Taku
Furudate, Sadanori
Kakizaki, Aya
Iizawa, Osamu
Aiba, Setsuya
author_facet Sato, Yota
Fujimura, Taku
Furudate, Sadanori
Kakizaki, Aya
Iizawa, Osamu
Aiba, Setsuya
author_sort Sato, Yota
collection PubMed
description Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.
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spelling pubmed-52162042017-01-18 M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site Sato, Yota Fujimura, Taku Furudate, Sadanori Kakizaki, Aya Iizawa, Osamu Aiba, Setsuya Case Rep Dermatol Single Case Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site. S. Karger AG 2016-07-19 /pmc/articles/PMC5216204/ /pubmed/28101015 http://dx.doi.org/10.1159/000447709 Text en Copyright © 2016 the Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Sato, Yota
Fujimura, Taku
Furudate, Sadanori
Kakizaki, Aya
Iizawa, Osamu
Aiba, Setsuya
M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title_full M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title_fullStr M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title_full_unstemmed M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title_short M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site
title_sort m2-polarized macrophages compose lupus vulgaris arising from a bacillus calmette-guérin vaccination site
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216204/
https://www.ncbi.nlm.nih.gov/pubmed/28101015
http://dx.doi.org/10.1159/000447709
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