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Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy

BACKGROUND AND OBJECTIVES: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis o...

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Autores principales: Shaheen, Asmat, Nazli, Rubina, Fatima, Sadia, Ali, Roshan, Khan, Ihsanullah, Khattak, Salim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216293/
https://www.ncbi.nlm.nih.gov/pubmed/28083037
http://dx.doi.org/10.12669/pjms.326.10917
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author Shaheen, Asmat
Nazli, Rubina
Fatima, Sadia
Ali, Roshan
Khan, Ihsanullah
Khattak, Salim
author_facet Shaheen, Asmat
Nazli, Rubina
Fatima, Sadia
Ali, Roshan
Khan, Ihsanullah
Khattak, Salim
author_sort Shaheen, Asmat
collection PubMed
description BACKGROUND AND OBJECTIVES: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women. METHODS: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student’s t test was performed to evaluate the mean differences in patients and control. RESULTS: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value<0.001).: Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value<0.001). CONCLUSION: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.
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spelling pubmed-52162932017-01-12 Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy Shaheen, Asmat Nazli, Rubina Fatima, Sadia Ali, Roshan Khan, Ihsanullah Khattak, Salim Pak J Med Sci Original Article BACKGROUND AND OBJECTIVES: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women. METHODS: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student’s t test was performed to evaluate the mean differences in patients and control. RESULTS: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value<0.001).: Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value<0.001). CONCLUSION: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women. Professional Medical Publications 2016 /pmc/articles/PMC5216293/ /pubmed/28083037 http://dx.doi.org/10.12669/pjms.326.10917 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shaheen, Asmat
Nazli, Rubina
Fatima, Sadia
Ali, Roshan
Khan, Ihsanullah
Khattak, Salim
Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title_full Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title_fullStr Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title_full_unstemmed Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title_short Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
title_sort adipokine serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216293/
https://www.ncbi.nlm.nih.gov/pubmed/28083037
http://dx.doi.org/10.12669/pjms.326.10917
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