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Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus

OBJECTIVE: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). METHODS: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (200...

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Autores principales: Arshad, Rabia, Kanpurwala, Muhammad Adnan, Karim, Nasim, Hassan, Jahan Ara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216313/
https://www.ncbi.nlm.nih.gov/pubmed/28083057
http://dx.doi.org/10.12669/pjms.326.10872
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author Arshad, Rabia
Kanpurwala, Muhammad Adnan
Karim, Nasim
Hassan, Jahan Ara
author_facet Arshad, Rabia
Kanpurwala, Muhammad Adnan
Karim, Nasim
Hassan, Jahan Ara
author_sort Arshad, Rabia
collection PubMed
description OBJECTIVE: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). METHODS: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology. RESULTS: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant. CONCLUSION: Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group.
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spelling pubmed-52163132017-01-12 Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus Arshad, Rabia Kanpurwala, Muhammad Adnan Karim, Nasim Hassan, Jahan Ara Pak J Med Sci Original Article OBJECTIVE: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM). METHODS: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology. RESULTS: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant. CONCLUSION: Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group. Professional Medical Publications 2016 /pmc/articles/PMC5216313/ /pubmed/28083057 http://dx.doi.org/10.12669/pjms.326.10872 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Arshad, Rabia
Kanpurwala, Muhammad Adnan
Karim, Nasim
Hassan, Jahan Ara
Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title_full Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title_fullStr Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title_full_unstemmed Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title_short Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus
title_sort effects of diet and metformin on placental morphology in gestational diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216313/
https://www.ncbi.nlm.nih.gov/pubmed/28083057
http://dx.doi.org/10.12669/pjms.326.10872
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